Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Peskar, BM; Wong, HC; Walsh, JH; Holzer, P.
A monoclonal antibody to calcitonin gene-related peptide abolishes capsaicin-induced gastroprotection.
EUR J PHARMACOL 1993 250: 201-203.
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Autor/innen der Med Uni Graz:
Holzer Peter
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Abstract:
Calcitonin gene-related peptide (CGRP) released from vasodilator nerves is implicated in the gastroprotective action of capsaicin. This experimental paradigm was used to prove the effectiveness of a monoclonal anti-CGRP antibody. The experiments were performed in anaesthetized rats in which intragastric capsaicin (0.5 mg/kg) reduced gastric injury due to ethanol (50%) by 72%. The protective effect of capsaicin was abolished by close arterial administration of the anti-CGRP antibody #4901 (5 mg) to the stomach. A monoclonal antibody to keyhole limpet haemocyanin was without effect. These data establish anti-CGRP antibody #4901 as a tool to neutralize endogenously released CGRP and show that CGRP is indispensable for the gastroprotective action of capsaicin.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Antibodies, Monoclonal - physiology
Calcitonin Gene-Related Peptide - immunology
Capsaicin - pharmacology
Ethanol - toxicity
Gastric Mucosa - drug effects
Hemocyanin - immunology
Injections, Intra-Arterial - immunology
Male - immunology
Rats - immunology
Rats, Wistar - immunology
Research Support, Non-U.S. Gov't - immunology
Research Support, U.S. Gov't, P.H.S. - immunology

Find related publications in this database (Keywords)
Capsaicin
CGRP (Calcitonin Gene-Related Peptide)
Monoclonal Anti-CGRP Antibody
Immuno-Neutralization
Gastric Mucosa
Gastric Mucosal Protection
Gastric Mucosal Injury
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