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Gewählte Publikation:

Weisser, J; Martin, J; Bisping, E; Maier, LS; Beyersdorf, F; Hasenfuss, G; Pieske, B.
Influence of mild hypothermia on myocardial contractility and circulatory function.
Basic Res Cardiol. 2001; 96(2):198-205 Doi: 10.1007/s003950170071
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Führende Autor*innen der Med Uni Graz
Pieske Burkert Mathias
Co-Autor*innen der Med Uni Graz
Bisping Egbert Hubertus

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Myocardial contractility depends on temperature. We investigated the influence of mild hypothermia (37-31 degrees C) on isometric twitch force, sarcoplasmic reticulum (SR) Ca2+-content and intracellular Ca2+-transients in ventricular muscle strips from human and porcine myocardium, and on in vivo hemodynamic parameters in pigs. In vitro experiments: muscle strips from 5 nonfailing human and 8 pig hearts. Electrical stimulation (1 Hz), simultaneous recording of isometric force and rapid cooling contractures (RCCs) as an indicator of SR Ca2+-content, or intracellular Ca2+-transients (aequorin method). In vivo experiments: 8 pigs were monitored with Millar-Tip (left ventricle) and Swan-Ganz catheter (pulmonary artery). Hemodynamic parameters were assessed at baseline conditions (37 degrees C), and after stepwise cooling on cardiopulmonary bypass to 35, 33 and 31 degrees C. Hypothermia increased isometric twitch force significantly by 91 +/- 16 % in human and by 50 +/- 9 % in pig myocardium (31 vs. 37 degrees C; p < 0.05, respectively). RCCs or aequorin light emission did not change significantly. In anesthetized pigs, mild hypothermia resulted in an increase in hemodynamic parameters of myocardial contractility. While heart rate decreased from 111 +/- 3 to 73 +/- 1 min(-1), cardiac output increased from 2.4 +/- 0.1 to 3.1 +/- 0.31/min, and stroke volume increased from 21 +/- 1 to 41 +/- 3 ml. +dP/dtmax increased by 25 +/- 8% (37 vs. 31 degrees C; p < 0.05 for all values). Systemic and pulmonary vascular resistance did not change significantly during cooling. Mild hypothermia exerts significant positive inotropic effects in human and porcine myocardium without increasing intracellular Ca2+-transients or SR Ca2+-content. These effects translate into improved hemodynamic parameters of left ventricular function.
Find related publications in this database (using NLM MeSH Indexing)
Aequorin -
Animals -
Calcium - metabolism
Coronary Circulation - physiology
Heart Failure - physiopathology Heart Failure - therapy
Hypothermia, Induced -
Isometric Contraction - physiology
Myocardial Contraction - physiology
Stroke Volume - physiology
Swine -
Vascular Resistance - physiology
Ventricular Function, Left - physiology
Ventricular Pressure - physiology

Find related publications in this database (Keywords)
contractile function
heart failure
ventricular function
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