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Vrenken, H; Pouwels, PJ; Ropele, S; Knol, DL; Geurts, JJ; Polman, CH; Barkhof, F; Castelijns, JA.
Magnetization transfer ratio measurement in multiple sclerosis normal-appearing brain tissue: limited differences with controls but relationships with clinical and MR measures of disease.
Mult Scler. 2007; 13(6):708-716 Doi: 10.1177/1352458506075521
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Co-Autor*innen der Med Uni Graz
Ropele Stefan

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We investigated the magnetization transfer ratio (MTR) of normal-appearing white (NAWM) and grey matter (NAGM) in a relatively large group of multiple sclerosis (MS) patients, and the relations of MTR changes with clinical disability. MTR was measured in 66 MS patients (12 PP, 35 RR, 19 SP) and 23 healthy controls, using a whole-brain 3D-FLASH technique corrected post-hoc for B1-induced variation. Histogram parameters of conservatively selected NAWM and cortical NAGM were analysed using Bonferroni-corrected ANOVA with age as covariate. Additionally, manually outlined regions of interest were analysed using a multilevel method. Lesions had low MTR (mean 22.7+/-6.9%), but NAWM exhibited limited changes: MTR histogram peak position was 32.8+/-1.0% in controls and 32.4+/-0.9% in MS patients, with a significant decrease compared to controls only in SPMS patients (31.9+/-1.1%, p=0.045). Cortical NAGM histograms did not differ significantly between patients and controls. In SPMS, regional mean MTR was significantly decreased in corpus callosum and hippocampus. MTR histogram parameters of NAGM and NAWM were correlated with EDSS and MSFC scores, with lesion volume and with normalized brain volume. We conclude that disease-induced MTR changes were small in MS NAWM and NAGM, but did correlate with clinical decline, lesion volume and overall cerebral atrophy.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Brain - pathology
Caudate Nucleus - pathology
Cerebral Cortex - pathology
Humans - pathology
Magnetic Resonance Imaging - methods
Middle Aged - methods
Multiple Sclerosis - pathology
Multiple Sclerosis, Chronic Progressive - pathology
Multiple Sclerosis, Relapsing-Remitting - pathology
Periaqueductal Gray - pathology
Putamen - pathology
Reference Values - pathology
Thalamus - pathology

Find related publications in this database (Keywords)
B-1 correction
magnetization transfer
multiple sclerosis
normal-appearing brain tissue
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