Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Wilders-Truschnig, MM; Leb, G; Warnkross, H; Langsteger, W; Eber, O; Dimal, P; Brezinschek, HP; Brezinschek, R; Tiran, A; Den Hartog, MT.
Involvement of the immune system in iodine deficient goiter.
Thyroidology. 1992; 4(1): 53-55.
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Autor/innen der Med Uni Graz:
Brezinschek Hans-Peter
Tiran Andreas
Truschnig-Wilders Martini

Dimensions Citations:

Plum Analytics:
Iodine deficient goiters were studied by immunohistochemistry and showed extensive presence and typical arrangement of dendritic cells, known to have excellent antigen presenting capacity. These cells were positive for all MHC-class II epitopes and for ICAM-1. Epithelial follicle lining cells were also seen to be class II positive but lacked ICAM-1. Thyroglobulin seemed not to be iodinated at the C-terminal hormogenic site, as shown by reactions with monoclonal antibodies. Iodine therapy, as well as thyroxine therapy were effective in reducing thyroid size. Both forms of therapy were found to decrease the pretreatment levels of circulating thyroid growth stimulating immunoglobulins (TGI).
Find related publications in this database (using NLM MeSH Indexing)
Antibodies, Monoclonal - immunology
Cell Adhesion Molecules - immunology
Dendrites - immunology
Epitopes - immunology
Fluorescent Antibody Technique - immunology
Genes, MHC Class II - immunology
Goiter - drug therapy
Humans - drug therapy
Immune System - immunology
Immunohistochemistry - immunology
Iodine - deficiency
Thyroglobulin - metabolism

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