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Gewählte Publikation:

Richtig, E; Hoff, M; Rehak, P; Kapp, K; Hofmann-Wellenhof, R; Zalaudek, I; Poschauko, J; Uggowitzer, M; Kohek, P; Smolle, J.
Efficacy of superficial and deep regional hyperthermia combined with systemic chemotherapy and radiotherapy in metastatic melanoma.
J Dtsch Dermatol Ges. 2003; 1(8):635-642
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Autor/innen der Med Uni Graz:
Hofmann-Wellenhof Rainer
Kapp Karin S.
Rehak Peter
Richtig Erika
Smolle Josef
Zalaudek Iris
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Abstract:
Response rates of cutaneous-subcutaneous or lymph node metastases of melanoma to systemic chemotherapy are rather low. We report our clinical experience with superficial and deep regional hyperthermia in combination with radiotherapy and/or chemotherapy with carboplatin. We treated 15 patients with metastatic melanoma (6 men, 9 women; age 39-84 years, mean age 60 years) by using superficial or deep regional hyperthermia produced by electromagnetic energy. Superficial hyperthermia was delivered to skin or lymph node metastases in combination with radiochemotherapy in 12 patients, while deep regional hyperthermia was administered with an annular array applicator to lymph node metastases either in combination with radiochemotherapy (1 patient) or with carboplatin alone (2 patients). The clinical response was assessed by clinical evaluation and/or computer tomography and/or ultrasonography at monthly intervals. Both superficial and deep regional hyperthermia was well tolerated. We observed 5 complete local remissions (34%), 6 partial local remissions (40%) and 2 patients with stable disease (13%). The best results were obtained in cutaneous or retroperitoneal metastases. Local response can be achieved in inoperable metastatic melanoma using superficial or deep regional hyperthermia in combination with radiochemotherapy or chemotherapy.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Chemoradiotherapy - methods
Combined Modality Therapy -
Female -
Humans -
Hyperthermia, Induced - methods
Liver Neoplasms - pathology
Liver Neoplasms - secondary
Liver Neoplasms - therapy
Lung Neoplasms - pathology
Lung Neoplasms - secondary
Lung Neoplasms - therapy
Lymphatic Metastasis - pathology
Male -
Melanoma - pathology
Melanoma - secondary
Melanoma - therapy
Middle Aged -
Neoplasm Staging -
Retroperitoneal Neoplasms - pathology
Retroperitoneal Neoplasms - secondary
Retroperitoneal Neoplasms - therapy
Skin Neoplasms - pathology
Skin Neoplasms - secondary
Skin Neoplasms - therapy
Treatment Outcome -

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