Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Iberer, F; Tscheliessnigg, K; Halwachs, G; Rehak, P; Wasler, A; Petutschnigg, B; Schreier, G; Müller, H; Allmayer, T; Freigassner, M; Prenner, G; Hipmair, G; Grasser, B.
Definitions of cytomegalovirus disease after heart transplantation: antigenemia as a marker for antiviral therapy.
Transpl Int. 1996; 9(3):236-242
Doi: 10.1007/BF00335392
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- Führende Autor*innen der Med Uni Graz
- Iberer Florian
- Co-Autor*innen der Med Uni Graz
- Baumann Gabriele
- Müller Helmut
- Prenner Günther
- Rehak Peter
- Tscheliessnigg Karlheinz
- Wasler Andrae
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- Abstract:
- In this prospective study, cytomegalovirus (CMV) antigenemia was defined as the marker for initiation and episodes of antigenemia as the indicator for the duration of antiviral therapy (CMV hyperimmune globulin and ganciclovir). The CMV antigenemia assay and CMV-specific IgM and IgG antibody tests were used to monitor CMV infection in 22 heart transplant recipients who, between October 1992 and July 1994, were followed up for 6 months. A total of 178 out of 627 antigenemia assays tested positive. The highest number of positive cells was greater after primary infection than after either reactivation (43.3 vs 0.3; P < 0.01) or reinfection (43.3 vs 9.3; P = NS). Sixty episodes of antigenemia were observed. More episodes of antigenemia were seen after primary infection than after either reactivation (4.6 vs 0.2; P < 0.01) or reinfection (4.6 vs 2.2; P = NS). The detection of antigenemia indicated the initiation of antiviral therapy within 24 h after the blood sample was harvested. Therapy was stopped immediately after a subsequent negative result became available. Our experience indicates that antigenemia directed antiviral therapy prevents CMV disease after primary and secondary infection in heart transplant recipients.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Antibodies, Viral - blood
- Antigens, Viral - blood
- Antiviral Agents - therapeutic use
- Cytomegalovirus - isolation & purification
- Cytomegalovirus Infections - diagnosis Cytomegalovirus Infections - etiology Cytomegalovirus Infections - therapy
- Female -
- Follow-Up Studies -
- Ganciclovir - therapeutic use
- Heart Transplantation -
- Humans -
- Immunoglobulin G - blood
- Immunoglobulin M - blood
- Immunoglobulins - therapeutic use
- Male -
- Middle Aged -
- Postoperative Complications -
- Predictive Value of Tests -
- Prospective Studies -
- Recurrence -
- Find related publications in this database (Keywords)
- CMV
- heart transplantation
- heart transplantation
- CMV
- antigenemia
- CMV