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Greimel, ER; Bjelic-Radisic, V; Pfisterer, J; Hilpert, F; Daghofer, F; du Bois, A; Arbeitsgemeinschaft Gynaekologische Onkologie Ovarian Cancer Study Group.
Randomized study of the Arbeitsgemeinschaft Gynaekologische Onkologie Ovarian Cancer Study Group comparing quality of life in patients with ovarian cancer treated with cisplatin/paclitaxel versus carboplatin/paclitaxel.
J CLIN ONCOL. 2006; 24(4): 579-586. Doi: 10.1200/JCO.2005.02.4067 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Greimel Elfriede Renate
Co-Autor*innen der Med Uni Graz
Bjelic-Radisic Vesna

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Purpose The objective of this study was to compare the quality of life (QoL) of ovarian cancer patients treated with paclitaxel/carboplatin (TC) versus paclitaxel/cisplatin (PT) and to determine the impact of treatment toxicity on the various QoL domains. Patients and Methods In this phase III trial, 798 patients with ovarian cancer stages IIB-IV were randomly assigned to receive TC or PT. The primary end point was progression-free survival; secondary end points included toxicity, QoL, and response to treatment. Patients completed the European Organisation for Research and Treatment of Cancer QLQ-C30 before treatment, within 3 days before the second and the fourth chemotherapy cycle, and 3 weeks after completion of chemotherapy. Results Previously reported data showed that patients undergoing TC or PT did not differ in progression-free survival and overall survival. However, the TIC arm was superior, indicating a better overall QoL compared with the PT arm. Controlling for toxicity and age, a significant treatment by assessment time interaction was found for four QoL functioning scales and three symptoms scales. Patients in the TC arm showed better means scores after treatment on overall QoL (P = .012), physical functioning (P = .012), role functioning (P = .005), and cognitive functioning (P = .024), compared with the PT arm. Concerning symptom experience, patients undergoing TC showed less nausea and vomiting (P < .001), less appetite loss (P < .001), and less fatigue (P = .033) after completion of treatment compared with patients undergoing PT. Conclusion The TC regimen achieved better QoL outcomes compared with the PT regimen. Thus, clinicians may consider replacing cisplatin with carboplatin when treating ovarian cancer patients with chemotherapy.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Analysis of Variance -
Antineoplastic Agents, Phytogenic - administration & dosage
Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Antineoplastic Combined Chemotherapy Protocols -
Carboplatin - administration & dosage Carboplatin - adverse effects
Cisplatin - administration & dosage Cisplatin - adverse effects
Disease-Free Survival -
Drug Administration Schedule -
Female -
Female -
Humans -
Infusions, Intravenous -
Middle Aged -
Neoplasm Staging -
Ovarian Neoplasms - drug therapy Ovarian Neoplasms - pathology
Paclitaxel - administration & dosage Paclitaxel - adverse effects
Quality of Life -
Questionnaires -
Survival Analysis -
Treatment Outcome -

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