Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Rienmüller, R; Brekke, O; Kampenes, VB; Reiter, U.
Dimeric versus monomeric nonionic contrast agents in visualization of coronary arteries.
Eur J Radiol. 2001; 38(3):173-178
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Autor/innen der Med Uni Graz:
Reiter Ursula
Rienmüller Rainer
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Abstract:
A cubital intravenous iodine contrast agent enhancement is used to visualize coronary arteries using EBT. The quality of the coronary artery visualization however is limited by the nearly simultaneous approximation of CT values in coronary arteries and myocardial tissue. The objective of the study was to evaluate if "under real clinical circumstances" the lower iodine concentration and the dimeric based characteristic of iodixanol may effect the kinetic of the applied contrast agent and the visualization of coronary arteries studied noninvasively by EBT. A double-blind, randomized, parallel study was performed in 111 cardiac patients, using iodixanol 270 mg I/ml or iohexol 300 mg I/ml. The kinetics of contrast enhancement was studied in the flow mode measuring following parameters: mean arrival time and mean time to reach peak CT values in the pulmonary trunk, transit time from the pulmonary trunk to the aorta as well as mean and maximum CT values in the left ventricular chamber and in the myocardium with respect to the body mass index. The mean difference of CT values in the left ventricular chamber and the myocardium was calculated. The length of the visualized coronary arteries was assessed and the diagnostic quality of coronary artery visualization scored on a visual analogue scale. Although iodixanol was used with a lower iodine concentration than iohexol there was no significant statistical difference between both groups with respect to the diagnostic visualization and length assessment of the coronary arteries as well as in the mean difference of CT values in the left ventricular chamber and the myocardium. This means that the advantageous dimeric characteristics of iodixanol may be used to reduce the amount of applicated iodine in contrast agents without loss of diagnostic image quality and information.
Find related publications in this database (using NLM MeSH Indexing)
Contrast Media -
Coronary Angiography -
Coronary Disease - radiography
Double-Blind Method - radiography
Electrocardiography - radiography
Female - radiography
Heart - radionuclide imaging
Heart Ventricles - radiography
Humans - radiography
Iohexol - diagnostic use
Male - diagnostic use
Middle Aged - diagnostic use
Tomography, X-Ray Computed - diagnostic use
Triiodobenzoic Acids - diagnostic use

Find related publications in this database (Keywords)
iodixanol
iohexol
coronary artery imaging
electron beam computed tomography
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