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Gewählte Publikation:

Kaufmann, P; Huppertz, B; Frank, HG.
The fibrinoids of the human placenta: origin, composition and functional relevance.
ANN ANATOMY 1996 178: 485-501.
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Autor/innen der Med Uni Graz:
Huppertz Berthold
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Abstract:
Placental fibrinoids are extracellularly deposited materials which are histologically glossy and acid staining, and can be found in every normal and pathological placenta at all stages of pregnancy. The amount of fibrinoid is, in general, independent of pregnancy outcome and fetal wellbeing. According to new findings, the classical histological term "fibrinoid" covers two distinctive extracellular matrices which differ as regards structure, composition and function. Fibrin-type fibrinoid is mostly composed of fibrin together with other molecules derived from blood clotting or degenerative processes. It is mainly a maternal blood-clot product which is used (a) to adapt the intervillous space to optimized flow conditions and (b) to control growth of the villous trees by encasing new villous branches which caused intervillous stasis or turbulence of maternal blood. Moreover, fibrin-type fibrinoid replaces degenerative syncytiotrophoblast at the maternofetal exchange surfaces, thus acting as a kind of substitute barrier. Matrix-type fibrinoid is a secretory product of invasive extravillous trophoblast cells. It shares some similarities with basement membranes, however, it is secreted in an apolar fashion, embedding the secreting cells. Like basement membranes, it contains laminins, collagen IV, and heparan sulfate. In addition, oncofetal fibronectins, vitronectin, and i-glycosylated molecules but no collagens I, III, and VII can be found. Matrix-type fibrinoid is thought to regulate trophoblast invasion by specific interactions with cell surface integrins. As a kind of "glue", it anchors the placenta to the uterine wall and seems to play an important role in materno-fetal immune interactions at this particular site. Both types of fibrinoid are usually co-localized, thus indicating close morphogenetic and functional interrelations.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Extracellular Matrix - pathology
Extracellular Matrix Proteins - analysis
Female - analysis
Fibrin - analysis
Humans - analysis
Placenta - cytology
Pregnancy - cytology
Trophoblasts - cytology

Find related publications in this database (Keywords)
human placenta
fibrinoid
extracellular matrix
extravillous trophoblast
fibronectin
blood clotting
oncofetal antigens
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