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Gewählte Publikation:

Schumacher, M; Eber, B; Dusleag, J; Fruhwald, FM; Zweiker, R; Pokan, R; Klein, W.
Thrombosis of a prosthetic mitral valve in the anticardiolipin syndrome
Dtsch Med Wochenschr. 1995; 120(22):795-798 Doi: 10.1055/s-2008-1055410 (- Case Report)
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Führende Autor*innen der Med Uni Graz
Schumacher Martin
Co-Autor*innen der Med Uni Graz
Fruhwald Friedrich
Zweiker Robert

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A 40-year-old woman in whom the mitral valve had to be replaced with a prosthetic one (St. Jude's) had to be reoperated 8 months later because of endocarditis on the second prosthetic valve (Carbo-Medics). Four months later her general condition deteriorated progressively with cough and dyspnoea, requiring hospitalization. Auscultation revealed moist rales over both lung bases; heart sounds were distant but otherwise normal. The "international normalized ratio" was 2.5, while erythrocyte sedimentation rate, white cell count and C-reactive protein were normal. Transthoracic echocardiography demonstrated a hardly moving mitral valve prosthesis with an opening area of 0.8 cm. Subsequently this decreased further and measurement of the anticardiolipin antibody titre revealed an IgG fraction of 37.9 U/ml (normal up to 12 U/ml). Within 48 hours thrombolysis with streptokinase had increased the valve's opening area to 1.8 cm. The patient made an uneventful recovery under strict anticoagulation. This case illustrates that the anticardiolipin syndrome can be a cause of an otherwise unclear genesis.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Antibodies, Anticardiolipin - blood
Anticoagulants - administration and dosage
Antiphospholipid Syndrome - complications
Drug Therapy, Combination - complications
Female - complications
Heart Valve Prosthesis - complications
Heparin - administration and dosage
Humans - administration and dosage
Mitral Valve - administration and dosage
Prosthesis Failure - administration and dosage
Reoperation - administration and dosage
Streptokinase - administration and dosage
Thrombolytic Therapy - methods
Thrombosis - diagnosis

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