Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Stolba, U; Krepler, K; Pflug, R; Velikay, M; Wedrich, A; Binder, S.
Experimental vitreous and aqueous replacement with perfluorophenanthrene. Clinical, histologic, and electrophysiologic results.
Retina. 1997; 17(2):146-153
Web of Science PubMed


Autor/innen der Med Uni Graz:
Velikay-Parel Michaela
Wedrich Andreas

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Plum Analytics:
Purpose: Anterior and posterior segment changes of experimental vitreous and aqueous substitution with Perfluorophenanthrene were evaluated. Methods: In 28 rabbit eyes that underwent vitrectomy, tamponades of 1.2 cc Perfluorophenanthrene remained as long as 8 weeks under clinical and electrophysiologic control. Histologic examinations of the eyes were done 1, 2, 4, and 8 weeks after insertion of the tamponade. In an additional 15 rabbit eyes, Perfluorophenanthrene was injected into the anterior chamber, and in some cases it was removed after 2 and 4 weeks, respectively. Follow-up examinations, which were done no later than 12 weeks after injection, included clinical appearance, endothelial cell counts, corneal pachymetry, tonometry, and histopathology. Results: Histologically we found narrowing of the outer plexiform layer and single macrophages in the inferior retina after 2 weeks. Cell loss in the outer nuclear layer and wrinkling of the outer retinal layers were observed after 4 weeks, which lead to the development of irregularities of all layers inferiorly after 8 weeks. Electroretinograms showed unchanged b-wave amplitudes after maximal light stimulation at each examination, but separate interpretation of low light intensity responses showed a significant decrease in b-wave amplitudes 4 weeks after surgery. Anterior segment intolerance started with stromal edema on the second day after surgery; corneal vascularization and scar formation occurred subsequently. Inferior endothelial cell density decreased to about 50%. Histologically inflammatory reactions, vacuolization of the inferior trabecular meshwork, and closure of the chamber angle between 5 and 7 o'clock were observed. Conclusions: Perfluorophenanthrene is only suitable for very short-term vitreous replacement unless prolapsing into the anterior chamber. Damages to the retina were observed 2 weeks after surgery.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Anterior Chamber - surgery
Aqueous Humor - drug effects
Cell Count -
Contrast Media - adverse effects
Corneal Edema - chemically induced
Disease Models, Animal -
Electroretinography - drug effects
Fluorocarbons - adverse effects
Follow-Up Studies -
Intraocular Pressure -
Postoperative Complications - chemically induced
Prostheses and Implants - adverse effects
Rabbits -
Retina - drug effects
Retinal Diseases - chemically induced
Trabecular Meshwork - pathology
Vitrectomy -
Vitreous Body - drug effects

Find related publications in this database (Keywords)
animal experimentation
anterior chamber
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