Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Volkenandt, M; Cerroni, L; Rieger, E; Soyer, HP; Koch, O; Wienecke, R; Atzpodien, J; Bertino, JR; Kerl, H.
Analysis of the 14;18 translocation in cutaneous lymphomas using the polymerase chain reaction.
J Cutan Pathol. 1992; 19(5):353-356
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Autor/innen der Med Uni Graz:
Cerroni Lorenzo
Kerl Helmut
Soyer Hans Peter

Dimensions Citations:

Plum Analytics:
A series of 25 cutaneous B-cell lymphoid proliferations was analyzed for the presence of the (14; 18) translocation using the polymerase chain reaction. Junctional sequences of rearranged chromosomes 14 and 18 were amplified in vitro, and t (14; 18) specific sequences were detected in 1 of 14 primary cutaneous B-cell lymphomas, in 3 of 8 primary nodal B-cell lymphomas and in none of 3 B-cell pseudolymphomas. These results indicate that the t (14; 18) may occur in a small subset of primary cutaneous lymphoma. However, the difference in incidence of the t (14; 18) between primary nodal and primary cutaneous lymphomas suggests that different molecular mechanisms are involved in the pathogenesis of these lymphomas.
Find related publications in this database (using NLM MeSH Indexing)
Base Sequence -
Chromosomes, Human, Pair 14 -
Chromosomes, Human, Pair 18 -
DNA, Neoplasm - genetics
Gene Amplification -
Humans -
Immunohistochemistry -
Lymphoma, B-Cell - genetics
Molecular Sequence Data -
Polymerase Chain Reaction -
Skin Neoplasms - genetics
Translocation, Genetic -

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