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Dahaba, AA; Hagara, B; Fall, A; Rehak, PH; List, WF; Metzler, H.
Procalcitonin for early prediction of survival outcome in postoperative critically ill patients with severe sepsis.
Br J Anaesth. 2006; 97(4): 503-508. [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Dahaba Ashraf
Fall Astrid
Hagara Bianca
Metzler Helfried
Rehak Peter

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BACKGROUND: Identification of postoperative patients at high risk of dying early after intensive care unit (ICU) admission through a fast and readily available parameter may help in determining therapeutic interventions or further diagnostic procedures that could have an impact on patients' outcome. The aim of our study was to assess the utility of procalcitonin (PCT) and other readily available parameters, as useful early (days 1-3) predictors of mortality in postoperative patients diagnosed with severe sepsis within 24 h preceding their operation. METHODS: More than a period of 2 yr, subsets of 69 postoperative patients admitted with severe sepsis and 890 non-septic ICU patients were investigated. PCT, C-reactive protein (CRP) and sequential organ failure assessment (SOFA) score were recorded over the duration of ICU stay. RESULTS: PCT area under receiver operating characteristic (ROC) curve was 0.78 on day 3 and was highly predictive of fatal outcome (0.90) at day 6. Area under ROC curve of SOFA score was 0.85 on day 3 and remained in this range until day 6. Area under ROC curves on day 3 of CRP (0.61) was non-predictive and remained non-predictive over the duration of ICU stay. CONCLUSIONS: PCT exhibited no discriminative power early after ICU admission for prediction of mortality in critically ill patients with severe sepsis, compared with a high predictive power of SOFA score on day 3. However, using PCT could still serve as a useful complementary comparator for prediction of survival outcome using the SOFA score.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Biological Markers - blood
C-Reactive Protein - metabolism
Calcitonin - blood
Critical Illness - therapy
Female - therapy
Humans - therapy
Intensive Care - therapy
Length of Stay - therapy
Male - therapy
Middle Aged - therapy
Multiple Organ Failure - blood
Postoperative Complications - blood
Prognosis - blood
Protein Precursors - blood
ROC Curve - blood
Sepsis - blood
Severity of Illness Index - blood
Survival Analysis - blood

Find related publications in this database (Keywords)
receiver operating characteristic
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