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Gewählte Publikation:

Haller, M; Müller, W; Binder, H; Estelberger, W; Arnold, P.
Single-injection inulin clearance--a simple method for measuring glomerular filtration rate in dogs.
Res Vet Sci. 1998; 64(2):151-156 Doi: 10.1016/S0034-5288(98)90011-X
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The glomerular filtration rates (GFR) of 93 dogs of different breeds with a broad range of bodyweight were determined using an inulin single-injection method. Fifty-two dogs were used as controls, 21 dogs had suspected renal disease but serum creatinine in the normal range, and 20 dogs had elevated serum creatinine levels and a low urine specific gravity due to renal disease. Inulin was injected intravenously at a dosage of 100 mg kg(-1) bodyweight or 3000 mg m(-2) body surface. Blood samples were taken before and three, 20, 40, 80 and 120 minutes after injection. The total clearance was calculated from the decrease in the serum concentration of inulin using a two-compartment model. The range of GFR values was 83.5-144.3 ml min(-1) m(-2) in control dogs, 60.2-96.7 ml min(-1) m(-2) in dogs with suspected renal disease, 50.0-76.2 ml min(-1) m(-2) in dogs with suspected renal disease and polyuria/polydipsia, and 16.3-63.0 ml min(-1) m(-2) in dogs with azotaemic renal disease. The study indicates that single-injection inulin clearance is a cheap and simple tool for GFR measurements in small animal practice.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Creatinine - blood
Dog Diseases - blood
Dogs - blood
False Negative Reactions - blood
False Positive Reactions - blood
Female - blood
Glomerular Filtration Rate - physiology
Injections, Intravenous - physiology
Inulin - administration and dosage
Kidney Diseases - blood
Male - blood
Metabolic Clearance Rate - blood
Models, Biological - blood
Sensitivity and Specificity - blood

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