Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Chen, J; Haase, N; Haange, SB; Sucher, R; Münzker, J; Jäger, E; Schischke, K; Seyfried, F; von, Bergen, M; Hankir, MK; Krügel, U; Fenske, WK.
Roux-en-Y gastric bypass contributes to weight loss-independent improvement in hypothalamic inflammation and leptin sensitivity through gut-microglia-neuron-crosstalk.
Mol Metab. 2021; 48:101214
Doi: 10.1016/j.molmet.2021.101214
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PubMed
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- Co-Autor*innen der Med Uni Graz
- Sucher Robert
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- Abstract:
- OBJECTIVE: Hypothalamic inflammation and endoplasmic reticulum (ER) stress are extensively linked to leptin resistance and overnutrition-related diseases. Surgical intervention remains the most efficient long-term weight-loss strategy for morbid obesity, but mechanisms underlying sustained feeding suppression remain largely elusive. This study investigated whether Roux-en-Y gastric bypass (RYGB) interacts with obesity-associated hypothalamic inflammation to restore central leptin signaling as a mechanistic account for post-operative appetite suppression. METHODS: RYGB or sham surgery was performed in high-fat diet-induced obese Wistar rats. Sham-operated rats were fed ad libitum or by weight matching to RYGB via calorie restriction (CR) before hypothalamic leptin signaling, microglia reactivity, and the inflammatory pathways were examined to be under the control of gut microbiota-derived circulating signaling. RESULTS: RYGB, other than CR-induced adiposity reduction, ameliorates hypothalamic gliosis, inflammatory signaling, and ER stress, which are linked to enhanced hypothalamic leptin signaling and responsiveness. Mechanistically, we demonstrate that RYGB interferes with hypothalamic ER stress and toll-like receptor 4 (TLR4) signaling to restore the anorexigenic action of leptin, which most likely results from modulation of a circulating factor derived from the altered gut microbial environment upon RYGB surgery. CONCLUSIONS: Our data demonstrate that RYGB interferes with hypothalamic TLR4 signaling to restore the anorexigenic action of leptin, which most likely results from modulation of a circulating factor derived from the post-surgical altered gut microbial environment.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals - administration & dosage
- Caloric Restriction - administration & dosage
- Diet, High-Fat - adverse effects
- Disease Models, Animal - administration & dosage
- Gastric Bypass - methods
- Gastrointestinal Microbiome - administration & dosage
- Hypothalamus - metabolism
- Inflammation - metabolism
- Leptin - metabolism
- Male - administration & dosage
- Microglia - metabolism
- Neurons - metabolism
- Obesity, Morbid - etiology, surgery
- Rats - administration & dosage
- Rats, Wistar - administration & dosage
- Signal Transduction - administration & dosage
- Treatment Outcome - administration & dosage
- Weight Loss - administration & dosage
- Find related publications in this database (Keywords)
- Roux-en-Y gastric Bypass
- Bariatric surgery
- Hypothalamic inflammation
- Endoplasmic reticulum stress
- Toll-like receptor 4
- Gut microbiota-brain axis