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Kuentzel, KB; Bradić, I; Mihalič, ZN; Korbelius, M; Rainer, S; Pirchheim, A; Kargl, J; Kratky, D.
Dysregulation of Placental Lipid Hydrolysis by High-Fat/High-Cholesterol Feeding and Gestational Diabetes Mellitus in Mice.
Int J Mol Sci. 2022; 23(20): 12286 Doi: 10.3390/ijms232012286 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Kratky Dagmar
Küntzel Katharina Barbara
Co-Autor*innen der Med Uni Graz
Bradic Ivan
Kargl Julia
Korbelius Melanie
Mihalic Zala Nikita
Pirchheim Anita
Rainer Silvia

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Advanced maternal age and obesity are the main risk factors to develop gestational diabetes mellitus (GDM). Obesity is a consequence of the increased storage of triacylglycerol (TG). Cytosolic and lysosomal lipid hydrolases break down TG and cholesteryl esters (CE) to release fatty acids (FA), free cholesterol, and glycerol. We have recently shown that intracellular lipases are present and active in the mouse placenta and that deficiency of lysosomal acid lipase alters placental and fetal lipid homeostasis. To date, intracellular lipid hydrolysis in GDM has been poorly studied despite the important role of FA in this condition. Therefore, we hypothesized that intracellular lipases are dysregulated in pregnancies complicated by maternal high-fat/high-cholesterol (HF/HCD) feeding with and without GDM. Placentae of HF/HCD-fed mice with and without GDM were more efficient, indicating increased nutrient transfer to the fetus. The increased activity of placental CE but not TG hydrolases in placentae of dams fed HF/HCD with or without GDM resulted in upregulated cholesterol export to the fetus and placental TG accumulation. Our results indicate that HF/HCD-induced dysregulation of placental lipid hydrolysis contributes to fetal hepatic lipid accumulation and possibly to fetal overgrowth, at least in mice.
Find related publications in this database (using NLM MeSH Indexing)
Humans - administration & dosage
Pregnancy - administration & dosage
Female - administration & dosage
Mice - administration & dosage
Animals - administration & dosage
Diabetes, Gestational - administration & dosage
Placenta - administration & dosage
Sterol Esterase - administration & dosage
Hydrolysis - administration & dosage
Cholesterol Esters - administration & dosage
Glycerol - administration & dosage
Fetal Macrosomia - administration & dosage
Obesity - complications
Fatty Acids - administration & dosage
Triglycerides - administration & dosage
Lipase - administration & dosage

Find related publications in this database (Keywords)
intracellular lipases
mouse placenta
gestational diabetes
maternal high-fat diet
fetal lipid accumulation
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