Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kuentzel, KB; Bradić, I; Mihalič, ZN; Korbelius, M; Rainer, S; Pirchheim, A; Kargl, J; Kratky, D.
Dysregulation of Placental Lipid Hydrolysis by High-Fat/High-Cholesterol Feeding and Gestational Diabetes Mellitus in Mice.
Int J Mol Sci. 2022; 23(20): 12286
Doi: 10.3390/ijms232012286
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- Führende Autor*innen der Med Uni Graz
- Kratky Dagmar
- Küntzel Katharina Barbara
- Co-Autor*innen der Med Uni Graz
- Bradic Ivan
- Kargl Julia
- Korbelius Melanie
- Mihalic Zala Nikita
- Pirchheim Anita
- Rainer Silvia
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- Abstract:
- Advanced maternal age and obesity are the main risk factors to develop gestational diabetes mellitus (GDM). Obesity is a consequence of the increased storage of triacylglycerol (TG). Cytosolic and lysosomal lipid hydrolases break down TG and cholesteryl esters (CE) to release fatty acids (FA), free cholesterol, and glycerol. We have recently shown that intracellular lipases are present and active in the mouse placenta and that deficiency of lysosomal acid lipase alters placental and fetal lipid homeostasis. To date, intracellular lipid hydrolysis in GDM has been poorly studied despite the important role of FA in this condition. Therefore, we hypothesized that intracellular lipases are dysregulated in pregnancies complicated by maternal high-fat/high-cholesterol (HF/HCD) feeding with and without GDM. Placentae of HF/HCD-fed mice with and without GDM were more efficient, indicating increased nutrient transfer to the fetus. The increased activity of placental CE but not TG hydrolases in placentae of dams fed HF/HCD with or without GDM resulted in upregulated cholesterol export to the fetus and placental TG accumulation. Our results indicate that HF/HCD-induced dysregulation of placental lipid hydrolysis contributes to fetal hepatic lipid accumulation and possibly to fetal overgrowth, at least in mice.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Pregnancy - administration & dosage
- Female - administration & dosage
- Mice - administration & dosage
- Animals - administration & dosage
- Diabetes, Gestational - administration & dosage
- Placenta - administration & dosage
- Sterol Esterase - administration & dosage
- Hydrolysis - administration & dosage
- Cholesterol Esters - administration & dosage
- Glycerol - administration & dosage
- Fetal Macrosomia - administration & dosage
- Obesity - complications
- Fatty Acids - administration & dosage
- Triglycerides - administration & dosage
- Lipase - administration & dosage
- Find related publications in this database (Keywords)
- intracellular lipases
- mouse placenta
- gestational diabetes
- maternal high-fat diet
- fetal lipid accumulation