Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Degoricija, V; Klobučar, I; Potočnjak, I; Dokoza, Terešak, S; Vidović, L; Pregartner, G; Berghold, A; Habisch, H; Madl, T; Frank, S.
Cholesterol Content of Very-Low-Density Lipoproteins Is Associated with 1-Year Mortality in Acute Heart Failure Patients.
BIOMOLECULES. 2022; 12(10):
Doi: 10.3390/biom12101542
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- Führende Autor*innen der Med Uni Graz
- Frank Sasa
- Co-Autor*innen der Med Uni Graz
- Berghold Andrea
- Habisch Hansjörg
- Madl Tobias
- Pregartner Gudrun
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- Abstract:
- Considering the relationship between the extent of metabolic derangement and the disease severity in heart failure, we hypothesized that the lipid content of very-low-density lipoprotein (VLDL) may have prognostic value for 1 year mortality in acute heart failure (AHF). Baseline serum levels of VLDL cholesterol (VLDL-C), VLDL triglycerides (VLDL-TG), VLDL phospholipids (VLDL-PL), and VLDL apolipoprotein B (VLDL-apoB) were measured using NMR spectroscopy. We calculated the ratios of the respective VLDL lipids and VLDL apoB (VLDL-C/VLDL-apoB, VLDL-TG/VLDL-apoB, and VLDL-PL/VLDL-apoB), as estimators of the cholesterol, triglyceride, and phospholipid content of VLDL particles and tested their association with mortality. Out of 315 AHF patients, 118 (37.5%) patients died within 1 year after hospitalization for AHF. Univariable Cox regression analyses revealed a significant inverse association of VLDL-C/VLDL-apoB (hazard ratio (HR) 0.43, 95% confidence interval (CI) 0.29-0.64, p < 0.001), VLDL-TG/VLDL-apoB (HR 0.79, 95% CI 0.71-0.88, p < 0.001), and VLDL-PL/VLDL-apoB (HR 0.37, 95% CI 0.25-0.56, p < 0.001) with 1 year mortality. Of the tested parameters, only VLDL-C/VLDL-apoB remained significant after adjustment for age and sex, as well as other clinical and laboratory parameters that showed a significant association with 1 year mortality in the univariable analyses. We conclude that cholesterol content of circulating VLDL (VLDL-C/VLDL-apoB) might be of prognostic value in AHF.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Cholesterol, VLDL - administration & dosage
- Lipoproteins, VLDL - chemistry, metabolism
- Cholesterol - administration & dosage
- Triglycerides - administration & dosage
- Apolipoproteins B - administration & dosage
- Heart Failure - administration & dosage
- Phospholipids - administration & dosage
- Find related publications in this database (Keywords)
- acute heart failure
- very-low-density lipoprotein
- mortality
- NMR spectroscopy
- prognostic biomarkers
- risk
- cholesterol