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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Zirngast, B; Berboth, L; Manninger, M; Hinghofer-Szalkay, H; Scherr, D; Petersen, LG; Goswami, N; Alogna, A; Maechler, H.
Impact of Increasing Lower Body Negative Pressure and Its Abrupt Release on Left Ventricular Hemodynamics in Anesthetized Pigs.
J Clin Med. 2022; 11(19): 5858 Doi: 10.3390/jcm11195858 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Mächler Heinrich
Zirngast Birgit
Co-Autor*innen der Med Uni Graz
Alogna Alessio
Goswami Nandu
Hinghofer-Szalkay Helmut
Manninger-Wünscher Martin
Scherr Daniel

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Lower body negative pressure (LBNP) has been implemented as a tool to simulate systemic effects of hypovolemia, understand orthostatic challenges and study G load stress in humans. However, the exact hemodynamic mechanisms of graded LBNP followed by its abrupt release have not been characterized in detail, limiting its potential applications in humans. Here, we set out to investigate the immediate hemodynamic alterations occurring during LBNP in healthy Landrace pigs. Invasive cardiac monitoring via extensive pressure volume loop analysis was carried out during application of incremental LBNP up to life threatening levels from -15 to -45 mmHg as well as during its abrupt release. Three different sealing positions were evaluated. Incremental LBNP consistently induced a preload dependent depression of systemic hemodynamics according to the Frank-Starling mechanism. Overall, the pressure-volume loop progressively shifted leftwards and downwards with increasing LBNP intensity. The abrupt release of LBNP reverted the above-described hemodynamic changes to baseline values within only three respiratory cycles. These data provide quantitative translational insights into hemodynamic mechanisms of incremental and very high levels of LBNP, levels of seal and effect of abrupt release for future human applications, such as countermeasure development for long spaceflight.

Find related publications in this database (Keywords)
lower body negative pressure
invasive hemodynamics
pressure-volume loops
preload reduction
Landrace pigs
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