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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Zhou, Q; Zhang, F; Kerbl-Knapp, J; Korbelius, M; Kuentzel, KB; Vujić, N; Akhmetshina, A; Hörl, G; Paar, M; Steyrer, E; Kratky, D; Madl, T.
Phosphatidylethanolamine N-Methyltransferase Knockout Modulates Metabolic Changes in Aging Mice.
BIOMOLECULES. 2022; 12(9): Doi: 10.3390/biom12091270 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Madl Tobias
Zhang Fangrong
Zhou Qishun
Co-Autor*innen der Med Uni Graz
Akhmetshina Alena
Hörl Gerd
Kerbl-Knapp Jakob
Korbelius Melanie
Kratky Dagmar
Küntzel Katharina Barbara
Paar Margret
Steyrer Ernst
Vujic Nemanja

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Phospholipid metabolism, including phosphatidylcholine (PC) biosynthesis, is crucial for various biological functions and is associated with longevity. Phosphatidylethanolamine N-methyltransferase (PEMT) is a protein that catalyzes the biosynthesis of PC, the levels of which change in various organs such as the brain and kidneys during aging. However, the role of PEMT for systemic PC supply is not fully understood. To address how PEMT affects aging-associated energy metabolism in tissues responsible for nutrient absorption, lipid storage, and energy consumption, we employed NMR-based metabolomics to study the liver, plasma, intestine (duodenum, jejunum, and ileum), brown/white adipose tissues (BAT and WAT), and skeletal muscle of young (9-10 weeks) and old (91-132 weeks) wild-type (WT) and PEMT knockout (KO) mice. We found that the effect of PEMT-knockout was tissue-specific and age-dependent. A deficiency of PEMT affected the metabolome of all tissues examined, among which the metabolome of BAT from both young and aged KO mice was dramatically changed in comparison to the WT mice, whereas the metabolome of the jejunum was only slightly affected. As for aging, the absence of PEMT increased the divergence of the metabolome during the aging of the liver, WAT, duodenum, and ileum and decreased the impact on skeletal muscle. Overall, our results suggest that PEMT plays a previously underexplored, critical role in both aging and energy metabolism.
Find related publications in this database (using NLM MeSH Indexing)
Aging - administration & dosage
Animals - administration & dosage
Liver - metabolism
Mice - administration & dosage
Mice, Knockout - administration & dosage
Phosphatidylcholines - administration & dosage
Phosphatidylethanolamine N-Methyltransferase - genetics, metabolism
Phospholipids - metabolism

Find related publications in this database (Keywords)
brown adipose tissue
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