Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Zhou, Q; Zhang, F; Kerbl-Knapp, J; Korbelius, M; Kuentzel, KB; Vujić, N; Akhmetshina, A; Hörl, G; Paar, M; Steyrer, E; Kratky, D; Madl, T.
Phosphatidylethanolamine N-Methyltransferase Knockout Modulates Metabolic Changes in Aging Mice.
BIOMOLECULES. 2022; 12(9):
Doi: 10.3390/biom12091270
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Madl Tobias
- Zhang Fangrong
- Zhou Qishun
- Co-Autor*innen der Med Uni Graz
- Akhmetshina Alena
- Hörl Gerd
- Kerbl-Knapp Jakob
- Korbelius Melanie
- Kratky Dagmar
- Küntzel Katharina Barbara
- Paar Margret
- Steyrer Ernst
- Vujic Nemanja
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- Abstract:
- Phospholipid metabolism, including phosphatidylcholine (PC) biosynthesis, is crucial for various biological functions and is associated with longevity. Phosphatidylethanolamine N-methyltransferase (PEMT) is a protein that catalyzes the biosynthesis of PC, the levels of which change in various organs such as the brain and kidneys during aging. However, the role of PEMT for systemic PC supply is not fully understood. To address how PEMT affects aging-associated energy metabolism in tissues responsible for nutrient absorption, lipid storage, and energy consumption, we employed NMR-based metabolomics to study the liver, plasma, intestine (duodenum, jejunum, and ileum), brown/white adipose tissues (BAT and WAT), and skeletal muscle of young (9-10 weeks) and old (91-132 weeks) wild-type (WT) and PEMT knockout (KO) mice. We found that the effect of PEMT-knockout was tissue-specific and age-dependent. A deficiency of PEMT affected the metabolome of all tissues examined, among which the metabolome of BAT from both young and aged KO mice was dramatically changed in comparison to the WT mice, whereas the metabolome of the jejunum was only slightly affected. As for aging, the absence of PEMT increased the divergence of the metabolome during the aging of the liver, WAT, duodenum, and ileum and decreased the impact on skeletal muscle. Overall, our results suggest that PEMT plays a previously underexplored, critical role in both aging and energy metabolism.
- Find related publications in this database (using NLM MeSH Indexing)
- Aging - administration & dosage
- Animals - administration & dosage
- Liver - metabolism
- Mice - administration & dosage
- Mice, Knockout - administration & dosage
- Phosphatidylcholines - administration & dosage
- Phosphatidylethanolamine N-Methyltransferase - genetics, metabolism
- Phospholipids - metabolism
- Find related publications in this database (Keywords)
- metabolomics
- NMR
- PEMT
- knockout
- aging
- mice
- liver
- intestine
- white
- brown adipose tissue