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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Meaton, I; Altokhis, A; Allen, CM; Clarke, MA; Sinnecker, T; Meier, D; Enzinger, C; Calabrese, M; De, Stefano, N; Pitiot, A; Giorgio, A; Schoonheim, MM; Paul, F; Pawlak, MA; Schmidt, R; Granziera, C; Kappos, L; Montalban, X; Rovira, À; Wuerfel, J; Evangelou, N.
Paramagnetic rims are a promising diagnostic imaging biomarker in multiple sclerosis.
Mult Scler. 2022; 28(14):2212-2220 Doi: 10.1177/13524585221118677 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Co-Autor*innen der Med Uni Graz
Enzinger Christian
Schmidt Reinhold

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BACKGROUND: White matter lesions (WMLs) on brain magnetic resonance imaging (MRI) in multiple sclerosis (MS) may contribute to misdiagnosis. In chronic active lesions, peripheral iron-laden macrophages appear as paramagnetic rim lesions (PRLs). OBJECTIVE: To evaluate the sensitivity and specificity of PRLs in differentiating MS from mimics using clinical 3T MRI scanners. METHOD: This retrospective international study reviewed MRI scans of patients with MS (n = 254), MS mimics (n = 91) and older healthy controls (n = 217). WMLs, detected using fluid-attenuated inversion recovery MRI, were analysed with phase-sensitive imaging. Sensitivity and specificity were assessed for PRLs. RESULTS: At least one PRL was found in 22.9% of MS and 26.1% of clinically isolated syndrome (CIS) patients. Only one PRL was found elsewhere. The identification of ⩾1 PRL was the optimal cut-off and had high specificity (99.7%, confidence interval (CI) = 98.20%-99.99%) when distinguishing MS and CIS from mimics and healthy controls, but lower sensitivity (24.0%, CI = 18.9%-36.6%). All patients with a PRL showing a central vein sign (CVS) in the same lesion (n = 54) had MS or CIS, giving a specificity of 100% (CI = 98.8%-100.0%) but equally low sensitivity (21.3%, CI = 16.4%-26.81%). CONCLUSION: PRLs may reduce diagnostic uncertainty in MS by being a highly specific imaging diagnostic biomarker, especially when used in conjunction with the CVS.
Find related publications in this database (using NLM MeSH Indexing)
Humans - administration & dosage
Multiple Sclerosis - diagnostic imaging
Retrospective Studies - administration & dosage
Diagnostic Imaging - administration & dosage
Demyelinating Diseases - administration & dosage
Biomarkers - administration & dosage

Find related publications in this database (Keywords)
Multiple sclerosis
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