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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Gampawar, P; Schmidt, R; Schmidt, H.
Telomere length and brain aging: A systematic review and meta-analysis.
Ageing Res Rev. 2022; 80: 101679 Doi: 10.1016/j.arr.2022.101679
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Führende Autor*innen der Med Uni Graz
Gampawar Piyush Gajananrao
Schmidt Helena
Co-Autor*innen der Med Uni Graz
Schmidt Reinhold

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The current evidence on the association of leukocyte telomere length (LTL) with age-related structural and cognitive changes in the brain is mixed. Herein conforming to PRISMA 2020 guidelines, we performed a systematic review and meta-analysis using data from 27 observational studies in non-demented individuals. We used effect size and p-value based meta-analysis methods considering marked heterogeneity among studies. We found that the longer LTL was associated with higher brain volume (β = 0.43, 95%CI: 0.36-0.50%, p = 0.008, N = 1102) and with higher global cognition (β = 0.01; 95%CI: 0.00-0.02, p = 0.03, N = 19609) by effect size based meta-analysis and with brain volume, hippocampal volume, global cognition, cognitive domains of attention/speed as well as executive functions by p-value based meta-analysis. No significant association of LTL with brain white matter hyperintensities was detected. Furthermore, the evidence strongly suggests a subgroup-specific canonical effect of telomeres, notably in older individuals and females. In conclusion, we provide meta-analytic evidence on the beneficial effect of telomeres on brain structure as well as cognition and advocate for a beneficial subgroup-specific effect that warrants further attention.

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