Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Sandner, SE; Zimpfer, D; Zrunek, P; Dunkler, D; Schima, H; Rajek, A; Grimm, M; Wolner, E; Wieselthaler, GM.
Renal function after implantation of continuous versus pulsatile flow left ventricular assist devices.
J Heart Lung Transplant. 2008; 27(5):469-73
Doi: 10.1016/j.healun.2007.12.012
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Zimpfer Daniel
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- Abstract:
- BACKGROUND: This study was designed to determine the effect of continuous vs pulsatile flow devices on renal function after left ventricular assist device (LVAD) implantation. METHODS: Ninety-two patients undergoing LVAD implantation as bridge-to-transplant therapy were retrospectively analyzed. Patients receiving continuous flow devices (n = 63, 68.5%) were compared with patients receiving pulsatile flow devices (n = 29, 31.5%). Renal function was assessed by 2 calculated glomerular filtration rates (GFR) using the Modification of Diet in Renal Disease (MDRD)-derived GFR (ml/min/1.73 m(2)) and the Cockcroft-Gault-derived creatinine clearance (CrCl, ml/min). RESULTS: Mean GFR/CrCl was comparable between the groups at LVAD implantation, in the post-implantation period, and at transplantation. Both groups had a significant increase in mean GFR at Week 1 post-implantation (continuous, 59.4 +/- 22.8 to 76.4 +/- 38.6, p = 0.001; pulsatile, 52.5 +/- 21.1 to 69.2 +/- 34.7; p = 0.007), Week 4 (continuous, 59.9 +/- 23.0 to 84.3 +/- 32.9; p < 0.001; pulsatile, 50.3 +/- 21.1 to 79.9 +/- 38.7, p = 0.007), and Week 12 (continuous, 60.3 +/- 23.1 to 75.3 +/- 30.2, p = 0.004; pulsatile, 55.5 +/- 23.1 to 74.2 +/- 27.2, p = 0.037) that was also seen with the Cockcroft-Gault-calculated CrCl. No significant increase occurred in mean GFR/CrCl to transplantation. Incidence of post-implantation renal failure was comparable between the groups (continuous, 38.1%; pulsatile, 31.0%; p = 0.512). CONCLUSIONS: After LVAD implantation, patients with continuous flow devices and patients with pulsatile flow devices have comparable renal function.
- Find related publications in this database (using NLM MeSH Indexing)
- Creatinine - blood
- Female - administration & dosage
- Glomerular Filtration Rate - administration & dosage
- Heart Failure - complications, surgery
- Heart-Assist Devices - administration & dosage
- Humans - administration & dosage
- Kidney - physiology
- Kidney Diseases - etiology
- Kidney Function Tests - administration & dosage
- Male - administration & dosage
- Middle Aged - administration & dosage
- Retrospective Studies - administration & dosage