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Dunst, B; Benedek, M; Koschutnig, K; Jauk, E; Neubauer, AC.
Sex differences in the IQ-white matter microstructure relationship: a DTI study.
Brain Cogn. 2014; 91: 71-8. Doi: 10.1016/j.bandc.2014.08.006 [OPEN ACCESS]
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Co-Autor*innen der Med Uni Graz
Jauk Emanuel

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Sex differences in the relationship between general intelligence and brain structure are a topic of increasing research interest. Early studies focused mainly on gray and white matter differences using voxel-based morphometry, while more recent studies investigated neural fiber tracts using diffusion tensor imaging (DTI) to analyze the white matter microstructure. In this study we used tract-based spatial statistics (TBSS) on DTI to test how intelligence is associated with brain diffusion indices and to see whether this relationship differs between men and women. 63 Men and women divided into groups of lower and higher intelligence were selected. Whole-brain DTI scans were analyzed using TBSS calculating maps of fractional anisotropy (FA), radial diffusivity (RD), and axial diffusivity (AD). The results reveal that the white matter microstructure differs between individuals as a function of intelligence and sex. In men, higher intelligence was related to higher FA and lower RD in the corpus callosum. In women, in contrast, intelligence was not related to the white matter microstructure. The higher values of FA and lower values of RD suggest that intelligence is associated with higher myelination and/or a higher number of axons particularly in men. This microstructural difference in the corpus callosum may increase cognitive functioning by reducing inter-hemispheric transfer time and thus account for more efficient brain functioning in men.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent - administration & dosage
Adult - administration & dosage
Anisotropy - administration & dosage
Cognition - physiology
Corpus Callosum - physiology
Diffusion Tensor Imaging - methods
Female - administration & dosage
Humans - administration & dosage
Intelligence - physiology
Male - administration & dosage
Middle Aged - administration & dosage
Nerve Fibers, Myelinated - physiology
Sex Characteristics - administration & dosage
White Matter - physiology
Young Adult - administration & dosage

Find related publications in this database (Keywords)
Corpus callosum
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