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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Hoenigl, M; Seidel, D; Carvalho, A; Rudramurthy, SM; Arastehfar, A; Gangneux, JP; Nasir, N; Bonifaz, A; Araiza, J; Klimko, N; Serris, A; Lagrou, K; Meis, JF; Cornely, OA; Perfect, JR; White, PL; Chakrabarti, A, , ECMM, and, ISHAM, collaborators.
The emergence of COVID-19 associated mucormycosis: a review of cases from 18 countries.
Lancet Microbe. 2022; 3(7):e543-e552 Doi: 10.1016/S2666-5247(21)00237-8 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Hönigl Martin

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Reports of COVID-19-associated mucormycosis have been increasing in frequency since early 2021, particularly among patients with uncontrolled diabetes. Patients with diabetes and hyperglycaemia often have an inflammatory state that could be potentiated by the activation of antiviral immunity to SARS-CoV2, which might favour secondary infections. In this Review, we analysed 80 published and unpublished cases of COVID-19-associated mucormycosis. Uncontrolled diabetes, as well as systemic corticosteroid treatment, were present in most patients with COVID-19-associated mucormycosis, and rhino-orbital cerebral mucormycosis was the most frequent disease. Mortality was high at 49%, which was particularly due to patients with pulmonary or disseminated mucormycosis or cerebral involvement. Furthermore, a substantial proportion of patients who survived had life-changing morbidities (eg, loss of vision in 46% of survivors). Our Review indicates that COVID-19-associated mucormycosis is associated with high morbidity and mortality. Diagnosis of pulmonary mucormycosis is particularly challenging, and might be frequently missed in India.
Find related publications in this database (using NLM MeSH Indexing)
COVID-19 - complications
Diabetes Mellitus - epidemiology
Humans - administration & dosage
Mucormycosis - complications
RNA, Viral - administration & dosage
Risk Factors - administration & dosage
SARS-CoV-2 - administration & dosage

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