Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Zhou, Q; Kerbl-Knapp, J; Zhang, F; Korbelius, M; Kuentzel, KB; Vujić, N; Akhmetshina, A; Hörl, G; Paar, M; Steyrer, E; Kratky, D; Madl, T.
Metabolomic Profiles of Mouse Tissues Reveal an Interplay between Aging and Energy Metabolism.
Metabolites. 2021; 12(1):
Doi: 10.3390/metabo12010017
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Kerbl-Knapp Jakob
- Madl Tobias
- Zhou Qishun
- Co-Autor*innen der Med Uni Graz
- Akhmetshina Alena
- Hörl Gerd
- Korbelius Melanie
- Kratky Dagmar
- Küntzel Katharina Barbara
- Paar Margret
- Steyrer Ernst
- Vujic Nemanja
- Zhang Fangrong
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Energy metabolism, including alterations in energy intake and expenditure, is closely related to aging and longevity. Metabolomics studies have recently unraveled changes in metabolite composition in plasma and tissues during aging and have provided critical information to elucidate the molecular basis of the aging process. However, the metabolic changes in tissues responsible for food intake and lipid storage have remained unexplored. In this study, we aimed to investigate aging-related metabolic alterations in these tissues. To fill this gap, we employed NMR-based metabolomics in several tissues, including different parts of the intestine (duodenum, jejunum, ileum) and brown/white adipose tissues (BAT, WAT), of young (9-10 weeks) and old (96-104 weeks) wild-type (mixed genetic background of 129/J and C57BL/6) mice. We, further, included plasma and skeletal muscle of the same mice to verify previous results. Strikingly, we found that duodenum, jejunum, ileum, and WAT do not metabolically age. In contrast, plasma, skeletal muscle, and BAT show a strong metabolic aging phenotype. Overall, we provide first insights into the metabolic changes of tissues essential for nutrient uptake and lipid storage and have identified biomarkers for metabolites that could be further explored, to study the molecular mechanisms of aging.
- Find related publications in this database (Keywords)
- aging
- NMR spectroscopy
- mice
- energy metabolism
- fat
- intestine
- metabolomics