Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kobayashi, H; Amrein, K; Lasky-Su, JA; Christopher, KB.
Procalcitonin metabolomics in the critically ill reveal relationships between inflammation intensity and energy utilization pathways.
Sci Rep. 2021; 11(1):23194
Doi: 10.1038/s41598-021-02679-0
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- Co-Autor*innen der Med Uni Graz
- Amrein Karin
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- Abstract:
- Procalcitonin is a biomarker of systemic inflammation and may have importance in the immune response. The metabolic response to elevated procalcitonin in critical illness is not known. The response to inflammation is vitally important to understanding metabolism alterations during extreme stress. Our aim was to determine if patients with elevated procalcitonin have differences in the metabolomic response to early critical illness. We performed a metabolomics study of the VITdAL-ICU trial where subjects received high dose vitamin D3 or placebo. Mixed-effects modeling was used to study changes in metabolites over time relative to procalcitonin levels adjusted for age, Simplified Acute Physiology Score II, admission diagnosis, day 0 25-hydroxyvitamin D level, and the 25-hydroxyvitamin D response to intervention. With elevated procalcitonin, multiple members of the short and medium chain acylcarnitine, dicarboxylate fatty acid, branched-chain amino acid, and pentose phosphate pathway metabolite classes had significantly positive false discovery rate corrected associations. Further, multiple long chain acylcarnitines and lysophosphatidylcholines had significantly negative false discovery rate corrected associations with elevated procalcitonin. Gaussian graphical model analysis revealed functional modules specific to elevated procalcitonin. Our findings show that metabolite differences exist with increased procalcitonin indicating activation of branched chain amino acid dehydrogenase and a metabolic shift.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged - administration & dosage
- Cholecalciferol - therapeutic use
- Critical Illness - therapy
- Energy Metabolism - drug effects
- Female - administration & dosage
- Humans - administration & dosage
- Inflammation - blood, metabolism, therapy
- Male - administration & dosage
- Metabolic Networks and Pathways - drug effects
- Metabolome - drug effects
- Metabolomics - administration & dosage
- Middle Aged - administration & dosage
- Placebo Effect - administration & dosage
- Procalcitonin - blood, metabolism
- Vitamins - therapeutic use