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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Dulz, S; Asselborn, NH; Dieckmann, KP; Matthies, C; Wagner, W; Weidmann, J; Seidel, C; Oing, C; Berger, LA; Alsdorf, W; Mankichian, B; Meyer, C; Vetterlein, MW; Gild, P; Ludwig, TA; Soave, A; Schriefer, P; Becker, A; Ahyai, SA; Oechsle, K; Bokemeyer, C; Wagenfeld, L; Fisch, M; Hartmann, M; Chun, FK; Kluth, LA.
Retinal toxicity after cisplatin-based chemotherapy in patients with germ cell cancer.
J Cancer Res Clin Oncol. 2017; 143(7):1319-1325 Doi: 10.1007/s00432-017-2384-8
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Co-Autor*innen der Med Uni Graz
Ahyai Sascha

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PURPOSE: Visual impairment represents an infrequent form of cisplatin-induced neurotoxicity; however, visual deterioration has been reported in several studies. To evaluate potential morphological and functional retinal alterations in patients with germ cell cancer (GCC) treated with cisplatin-based chemotherapy (CBC). METHODS: Multi-disciplinary and multi-institutional study design. Examination of 28 eyes of 14 male GCC patients, who had received at least one cycle of CBC. A matched control group of healthy, untreated patients were included in this study. Subjects underwent a retinal nerve fiber thickness (RNFL) measurement, color vision, visual acuity testing, full-field electroretinograms (ff-ERG). To assess a correlation between cumulative cisplatin dose and measured RNFL and ff-ERG Pearson correlation coefficient analysis was performed. RESULTS: Both study groups (CBC recipients vs. healthy controls) consisted each of 14 participants with a median patient age of 30 years (interquartile range (IQR) 26-37 years). Tumor histology was seminoma in 6 of 14 patients (43%), and non-seminomatous GCC in 8 of 14 patients (57%). Median cumulative cisplatin dosis at examination was 627 mg/m2 (IQR 413-1013 mg/m2). Morphological assessment revealed reduced RNFL in 11 of 14 patients (78.6%). Reduction in RNFL was significantly correlated to the cumulative CBC dose received (rho = + 0.70; p = 0.004). ff-ERG showed significant differences between CBC recipients and the control group in 2 of 5 tested categories (all p values <0.001). CONCLUSION: This study represents first evidence of chronic subclinical retinal toxicity due to cisplatin-based chemotherapy in patients with GCC. The reduction of RNFL might become clinically relevant in upcoming age-related chronic degenerative disorders such as glaucoma.
Find related publications in this database (using NLM MeSH Indexing)
Adult - administration & dosage
Antineoplastic Agents - adverse effects
Cisplatin - adverse effects
Electroretinography - administration & dosage
Humans - administration & dosage
Male - administration & dosage
Neoplasms, Germ Cell and Embryonal - drug therapy
Pilot Projects - administration & dosage
Retina - drug effects, pathology
Testicular Neoplasms - drug therapy
Tomography, Optical Coherence - administration & dosage

Find related publications in this database (Keywords)
Germ cell cancer
Testicular cancer
Retinal toxicity
Late effects
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