Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Semeraro, MD; Almer, G; Kaiser, M; Zelzer, S; Meinitzer, A; Scharnagl, H; Sedej, S; Gruber, HJ; Herrmann, M.
The effects of long-term moderate exercise and Western-type diet on oxidative/nitrosative stress, serum lipids and cytokines in female Sprague Dawley rats.
Eur J Nutr. 2022; 61(1):255-268
Doi: 10.1007/s00394-021-02639-4
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- Führende Autor*innen der Med Uni Graz
- Herrmann Markus
- Semeraro Maria Donatella
- Co-Autor*innen der Med Uni Graz
- Almer Gunter
- Gruber Hans-Jürgen
- Kaiser Melanie
- Meinitzer Andreas
- Scharnagl Hubert
- Sedej Simon
- Zelzer Sieglinde
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- Abstract:
- PURPOSE: Regular exercise reduces obesity and the risk of cardiovascular disease. However, health-promoting benefits of physical activity are commonly associated with increased inflammation and oxidative stress. Here, we tested whether constant moderate exercise is able to prevent or attenuate the oxidative/nitrosative stress, inflammation, and serum lipids in lean and obese rats. METHODS: Four-month-old female Sprague Dawley rats received standard or a high-fat diet. Animals were subjected to a physical activity protocol, consisting of 30 min forced treadmill exercise for 5 consecutive days per week during 10 months. Baseline and sedentary (non-exercised) rats were used as controls. Lipids, oxidized low-density lipoprotein cholesterol, nitric oxide metabolites, and pro- and anti-inflammatory markers were measured in blood collected upon euthanasia. RESULTS: At variance to young baseline control rats, 14-month-old animals fed normal diet had increased plasma lipid levels, including total cholesterol and triglycerides, which were further elevated in rats that consumed a high-fat diet. While treadmill exercise did not lower the amount of serum lipids in standard diet group, forced physical activity reduced non-high-density lipoprotein cholesterol in response to high-fat diet feeding. Exercised rats fed standard diet or high-fat diet had lower abundancy of nitric oxide metabolites, which coincided with increased levels of oxidized low-density lipoprotein cholesterol. Accordingly, the amount of nitric oxide metabolites correlated inversely with oxidized low-density lipoprotein cholesterol and homo-arginine. Exercise significantly reduced inflammatory cytokines in high-fat diet fed rats only. CONCLUSION: Our study suggests that regular exercise alters the equilibrium between oxidative and anti-oxidative compounds and reduces pro-inflammatory cytokines.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals - administration & dosage
- Cytokines - administration & dosage
- Diet, High-Fat - adverse effects
- Diet, Western - administration & dosage
- Female - administration & dosage
- Lipids - administration & dosage
- Nitrosative Stress - administration & dosage
- Oxidative Stress - administration & dosage
- Rats - administration & dosage
- Rats, Sprague-Dawley - administration & dosage
- Find related publications in this database (Keywords)
- Long-term moderate exercise
- Western-type diet
- Oxidized LDL
- Nitric oxide
- Nitric oxide synthase
- Sprague Dawley rats