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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Laansma, MA; Bright, JK; Al-Bachari, S; Anderson, TJ; Ard, T; Assogna, F; Baquero, KA; Berendse, HW; Blair, J; Cendes, F; Dalrymple-Alford, JC; de, Bie, RMA; Debove, I; Dirkx, MF; Druzgal, J; Emsley, HCA; Garraux, G; Guimarães, RP; Gutman, BA; Helmich, RC; Klein, JC; Mackay, CE; McMillan, CT; Melzer, TR; Parkes, LM; Piras, F; Pitcher, TL; Poston, KL; Rango, M; Ribeiro, LF; Rocha, CS; Rummel, C; Santos, LSR; Schmidt, R; Schwingenschuh, P; Spalletta, G; Squarcina, L; van, den, Heuvel, OA; Vriend, C; Wang, JJ; Weintraub, D; Wiest, R; Yasuda, CL; Jahanshad, N; Thompson, PM; van, der, Werf, YD, , ENIGMA-Parkinson's, Study.
International Multicenter Analysis of Brain Structure Across Clinical Stages of Parkinson's Disease.
Mov Disord. 2021; 36(11):2583-2594 Doi: 10.1002/mds.28706 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Co-Autor*innen der Med Uni Graz
Schmidt Reinhold
Schwingenschuh Petra

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BACKGROUND: Brain structure abnormalities throughout the course of Parkinson's disease have yet to be fully elucidated. OBJECTIVE: Using a multicenter approach and harmonized analysis methods, we aimed to shed light on Parkinson's disease stage-specific profiles of pathology, as suggested by in vivo neuroimaging. METHODS: Individual brain MRI and clinical data from 2357 Parkinson's disease patients and 1182 healthy controls were collected from 19 sources. We analyzed regional cortical thickness, cortical surface area, and subcortical volume using mixed-effects models. Patients grouped according to Hoehn and Yahr stage were compared with age- and sex-matched controls. Within the patient sample, we investigated associations with Montreal Cognitive Assessment score. RESULTS: Overall, patients showed a thinner cortex in 38 of 68 regions compared with controls (dmax  = -0.20, dmin  = -0.09). The bilateral putamen (dleft  = -0.14, dright  = -0.14) and left amygdala (d = -0.13) were smaller in patients, whereas the left thalamus was larger (d = 0.13). Analysis of staging demonstrated an initial presentation of thinner occipital, parietal, and temporal cortices, extending toward rostrally located cortical regions with increased disease severity. From stage 2 and onward, the bilateral putamen and amygdala were consistently smaller with larger differences denoting each increment. Poorer cognition was associated with widespread cortical thinning and lower volumes of core limbic structures. CONCLUSIONS: Our findings offer robust and novel imaging signatures that are generally incremental across but in certain regions specific to disease stages. Our findings highlight the importance of adequately powered multicenter collaborations. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Find related publications in this database (using NLM MeSH Indexing)
Brain - diagnostic imaging, pathology
Humans - administration & dosage
Magnetic Resonance Imaging - administration & dosage
Neuroimaging - administration & dosage
Parkinson Disease - complications
Thalamus - pathology

Find related publications in this database (Keywords)
Parkinson's disease
disease severity
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