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Fröhlich, E; Salar-Behzadi, S.
Oral inhalation for delivery of proteins and peptides to the lungs.
Eur J Pharm Biopharm. 2021; 163:198-211 Doi: 10.1016/j.ejpb.2021.04.003 [OPEN ACCESS]
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Fröhlich Eleonore

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Oral inhalation is the preferred route for delivery of small molecules to the lungs, because high tissue levels can be achieved shortly after application. Biologics are mainly administered by intravenous injection but inhalation might be beneficial for the treatment of lung diseases (e.g. asthma). This review discusses biological and pharmaceutical challenges for delivery of biologics and describes promising candidates. Insufficient stability of the proteins during aerosolization and the biological environment of the lung are the main obstacles for pulmonary delivery of biologics. Novel nebulizers will improve delivery by inducing less shear stress and administration as dry powder appears suitable for delivery of biologics. Other promising strategies include pegylation and development of antibody fragments, while carrier-encapsulated systems currently play no major role in pulmonary delivery of biologics for lung disease. While development of various biologics has been halted or has shown little effects, AIR DNase, alpha1-proteinase inhibitor, recombinant neuraminidase, and heparin are currently being evaluated in phase III trials. Several biologics are being tested for the treatment of coronavirus disease (COVID)-19, and it is expected that these trials will lead to improvements in pulmonary delivery of biologics. Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Administration, Inhalation -
Administration, Oral -
Animals -
Biological Products - administration & dosage
Drug Carriers - chemistry
Drug Delivery Systems - methods
Humans -
Lung - drug effects
Lung Diseases - drug therapy
Nebulizers and Vaporizers -
Peptides - administration & dosage
Powders - administration & dosage
Proteins - administration & dosage

Find related publications in this database (Keywords)
Drug delivery
Lung diseases
Protein delivery
ARDS treatment
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