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Gewählte Publikation:

Rössler, A; László, Z; Haditsch, B; Hinghofer-Szalkay, HG.
Orthostatic stimuli rapidly change plasma adrenomedullin in humans.
Hypertension. 1999; 34(5):1147-1151 Doi: 10.1161/01.HYP.34.5.1147 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Rössler Andreas
Co-Autor*innen der Med Uni Graz
Hinghofer-Szalkay Helmut

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The aim of this study was to evaluate the effect of orthostasis on the time course of plasma adrenomedullin concentration. On 5 different days, normotensive subjects were randomized to undergo for 30 minutes either 12 degrees, 30 degrees, 53 degrees, or 70 degrees passive head-up tilt or to remain supine. Venous blood was collected from each subject in the supine position before tilting, at 3 and 27 minutes during tilting, and at 2 and 50 minutes after orthostasis. Plasma adrenomedullin increased significantly with tilt of >/=30 degrees in a stimulus-dependent manner. Approximately half of the increase seen at 27 minutes occurred during the first 2 minutes of upright positioning; the maximum effect with 70 degrees tilt was +70%. Elevations in norepinephrine, epinephrine, aldosterone, plasma renin activity, vasopressin, heart rate, and mean arterial pressure were also significant. Hematocrit, blood density, plasma density, and plasma volume loss rose (P<0.05) at 53 degrees and 70 degrees tilt. Our results indicate that adrenomedullin may play an important role in stabilization of hemodynamics during passive orthostasis. In conclusion, plasma adrenomedullin rapidly increases with orthostatic challenge in a stimulus-dependent manner and also swiftly returns to baseline levels after the subject resumes the supine position.
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Adrenomedullin -
Adult -
Blood Pressure -
Catecholamines - blood
Heart Rate - blood
Humans - blood
Male - blood
Peptides - blood
Posture - blood
Vasodilator Agents - blood

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