Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kvietkauskas, M; Zitkute, V; Leber, B; Strupas, K; Stiegler, P; Schemmer, P.
The Role of Metabolomics in Current Concepts of Organ Preservation.
Int J Mol Sci. 2020; 21(18):
Doi: 10.3390/ijms21186607
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- Führende Autor*innen der Med Uni Graz
- Stiegler Philipp
- Co-Autor*innen der Med Uni Graz
- Leber Bettina
- Schemmer Peter
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- Abstract:
- In solid organ transplantation (Tx), both survival rates and quality of life have improved dramatically over the last few decades. Each year, the number of people on the wait list continues to increase, widening the gap between organ supply and demand. Therefore, the use of extended criteria donor grafts is growing, despite higher susceptibility to ischemia-reperfusion injury (IRI) and consecutive inferior Tx outcomes. Thus, tools to characterize organ quality prior to Tx are crucial components for Tx success. Innovative techniques of metabolic profiling revealed key pathways and mechanisms involved in IRI occurring during organ preservation. Although large-scale trials are needed, metabolomics appears to be a promising tool to characterize potential biomarkers, for the assessment of graft quality before Tx and evaluate graft-related outcomes. In this comprehensive review, we summarize the currently available literature on the use of metabolomics in solid organ Tx, with a special focus on metabolic profiling during graft preservation to assess organ quality prior to Tx.
- Find related publications in this database (Keywords)
- transplantation
- machine perfusion
- metabolomics
- preservation
- static cold storage