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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Kneihsl, M; Hofer, E; Enzinger, C; Niederkorn, K; Horner, S; Pinter, D; Fandler-Höfler, S; Eppinger, S; Haidegger, M; Schmidt, R; Gattringer, T.
Intracranial Pulsatility in Relation to Severity and Progression of Cerebral White Matter Hyperintensities.
Stroke. 2020; 51(11):3302-3309 Doi: 10.1161/STROKEAHA.120.030478
Web of Science PubMed FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Gattringer Thomas
Kneihsl Markus
Co-Autor*innen der Med Uni Graz
Enzinger Christian
Eppinger Sebastian
Fandler-Höfler Simon
Haidegger Melanie
Hofer Edith
Horner Susanna
Niederkorn Kurt
Pinter Daniela Theresia
Schmidt Reinhold

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BACKGROUND AND PURPOSE: Previous studies suggested an association between increased intracranial arterial pulsatility and the severity of microangiopathic white matter hyperintensities (WMH). However, possible confounders such as age and hypertension were seldomly considered and longitudinal data are lacking. We here aimed to explore whether increased middle cerebral artery pulsatility is associated with baseline severity and progression of cerebral small vessel disease-related WMH in elderly individuals. METHODS: The study population consisted of elderly participants from the community-based ASPS (Austrian Stroke Prevention Study). Baseline and follow-up assessment comprised transcranial Doppler sonography, brain magnetic resonance imaging, and clinical/laboratory examination of vascular risk factors. Pulsatility index on transcranial Doppler sonography was averaged from baseline indices of both middle cerebral arteries and was correlated with baseline WMH severity and WMH progression over a median follow-up period of 5 years in uni- and multivariable analyses. WMH severity was graded according to the Fazekas scale, and WMH load was quantified by semiautomated volumetric assessment. RESULTS: The study cohort comprised 491 participants (mean age: 60.7±6.9 years; female: 48.5%). Pulsatility index was increased in participants with more severe WMH at baseline (P<0.001) but was not associated with WMH progression during follow-up (rs: 0.097, P=0.099). In multivariable analyses, only arterial hypertension remained significantly associated with baseline severity (P=0.04) and progression (P=0.008) of WMH, although transcranial Doppler sonography pulsatility index was not predictive (P>0.1, respectively). CONCLUSIONS: This community-based cohort study of elderly individuals does not support the pulsatility index of the middle cerebral artery on transcranial Doppler sonography as an independent marker of microangiopathic WMH severity and progression over time.
Find related publications in this database (using NLM MeSH Indexing)
Aged - administration & dosage
Cerebral Small Vessel Diseases - diagnostic imaging, physiopathology
Cerebrovascular Circulation - administration & dosage
Disease Progression - administration & dosage
Female - administration & dosage
Humans - administration & dosage
Magnetic Resonance Imaging - administration & dosage
Male - administration & dosage
Middle Aged - administration & dosage
Middle Cerebral Artery - diagnostic imaging, physiopathology
Pulsatile Flow - administration & dosage
Severity of Illness Index - administration & dosage
Stroke, Lacunar - diagnostic imaging
Ultrasonography, Doppler, Transcranial - administration & dosage
White Matter - diagnostic imaging

Find related publications in this database (Keywords)
cerebral small vessel disease
pulsatile flow
risk factors
white matter
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