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SHR Neuro Krebs Kardio Lipid

Mutgan, AC; Besikcioglu, HE; Wang, S; Friess, H; Ceyhan, GO; Demir, IE.
Insulin/IGF-driven cancer cell-stroma crosstalk as a novel therapeutic target in pancreatic cancer.
Mol Cancer. 2018; 17(1): 66-66. [OPEN ACCESS]
PubMed PUBMED Central FullText FullText_MUG


Autor/innen der Med Uni Graz:
Mutgan Ayse Ceren

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Number of Figures: 3
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Pancreatic ductal adenocarcinoma (PDAC) is unrivalled the deadliest gastrointestinal cancer in the western world. There is substantial evidence implying that insulin and insulin-like growth factor (IGF) signaling axis prompt PDAC into an advanced stage by enhancing tumor growth, metastasis and by driving therapy resistance. Numerous efforts have been made to block Insulin/IGF signaling pathway in cancer therapy. However, therapies that target the IGF1 receptor (IGF-1R) and IGF subtypes (IGF-1 and IGF-2) have been repeatedly unsuccessful. This failure may not only be due to the complexity and homology that is shared by Insulin and IGF receptors, but also due to the complex stroma-cancer interactions in the pancreas. Shedding light on the interactions between the endocrine/exocrine pancreas and the stroma in PDAC is likely to steer us toward the development of novel treatments. In this review, we highlight the stroma-derived IGF signaling and IGF-binding proteins as potential novel therapeutic targets in PDAC.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Antineoplastic Agents - pharmacology
Cancer-Associated Fibroblasts - metabolism
Cancer-Associated Fibroblasts - pathology
Cell Communication - drug effects
Humans -
Insulin - metabolism
Pancreatic Neoplasms - drug therapy
Pancreatic Neoplasms - metabolism
Pancreatic Neoplasms - pathology
Signal Transduction - drug effects
Somatomedins - metabolism
Stromal Cells - metabolism
Stromal Cells - pathology

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