Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Terbuch, A; Posch, F; Bauernhofer, T; Pichler, M; Peinsith, H; Szkandera, J; Riedl, J; Hutterer, GC; Pummer, K; Partl, R; Kapp, KS; Stöger, H; Stotz, M; Gerger, A.
Age as a Predictor of Treatment Outcome in Metastatic Testicular Germ Cell Tumors.
Anticancer Res. 2019; 39(10):5589-5596
Doi: 10.21873/anticanres.13753
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Stotz Michael
- Terbuch Angelika
- Co-Autor*innen der Med Uni Graz
- Bauernhofer Thomas
- Gerger Armin
- Hutterer Georg
- Kapp Karin S.
- Partl Richard
- Pichler Martin
- Posch Florian
- Pummer Karl
- Riedl Jakob
- Stöger Herbert
- Szkandera Joanna
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- Abstract:
- To quantify the prognostic impact of age on relapse and mortality in patients with metastatic testicular germ cell tumors (TGCT). Electronical medical records of 1,225 TGCT patients who were treated at a single academic center between 1994 and 2015 were reviewed. Higher age did not predict for worse progression-free survival (PFS) or for higher progression risk. The corresponding 5-year PFS estimates were 85% in patients younger than 40 years and 83% in the elderly population. Although not statistically significant, higher age was numerically associated with worse overall survival (OS) (univariate HR per five years increase in age=1.18, 95%CI=0.99-1.41). This was explained in regression analysis where age predicted for significantly higher risk of treatment-related death (p=0.022). Elderly patients with metastatic TGCT can achieve high cure rates similar to younger patients if they tolerate risk-adapted chemotherapy. Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Age Factors -
- Disease Progression -
- Humans -
- Male -
- Neoplasms, Germ Cell and Embryonal - drug therapy
- Neoplasms, Germ Cell and Embryonal - pathology
- Prognosis -
- Progression-Free Survival -
- Recurrence -
- Retrospective Studies -
- Risk Factors -
- Testicular Neoplasms - drug therapy
- Testicular Neoplasms - pathology
- Treatment Outcome -
- Find related publications in this database (Keywords)
- Age
- testicular cancer
- germ cell tumors
- prognosis
- outcome
- chemotherapy