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Vujic, J; Schöllnast, H; Marsoner, K; Wienerroither, V; Bacher, H; Mischinger, HJ; Kornprat, P.
Marking Disappearing Colorectal Liver Metastases After Complete Response to Neoadjuvant Chemotherapy via CT - A Pilot Study.
Anticancer Res. 2019; 39(7): 3847-3854. [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Bacher Heinz
Kornprat Peter
Marsoner Katharina
Mischinger Hans-Joerg
Schöllnast Helmut
Wienerroither Valerie

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The liver is a frequent site for metastases of colorectal cancer. Approximately 15% of patients have hepatic metastases at the time of diagnosis and another 50% develop them over the course of their disease. Only 10-25% of patients are candidates for liver resection. The aim of this study was to assess the benefit of preoperative computed tomography (CT)-guided wire marking of disappearing colorectal liver metastases (CRLMs) (radiological disappearance of metastases) before surgical resection. Between January 2011 and January 2014, 20 patients with potentially disappearing CRLMs were selected for CT-guided wire marking. Following treatment with neoadjuvant chemotherapy, disappearing CRLMs were marked via CT guidance. Afterwards, the marked sites were resected. Complete histological response to neoadjuvant chemotherapy was only in 10 resected sites (18%), and 46 (82%) resected liver metastases showed metastatic tissue present. Both overall survival and the disease-free rates in patients after using our method were 55%. This study demonstrated the usefulness of CT-guided wire marking to mark disappearing CRLMs in order to improve long-term effectiveness of surgical treatment. Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Antineoplastic Agents - therapeutic use
Colorectal Neoplasms - diagnostic imaging
Colorectal Neoplasms - drug therapy
Colorectal Neoplasms - pathology
Colorectal Neoplasms - surgery
Female -
Humans -
Liver Neoplasms - diagnostic imaging
Liver Neoplasms - drug therapy
Liver Neoplasms - secondary
Liver Neoplasms - surgery
Male -
Middle Aged -
Neoadjuvant Therapy -
Pilot Projects -
Survival Analysis -
Tomography, X-Ray Computed -

Find related publications in this database (Keywords)
Disappearing liver metastases
wire marking
colon cancer
complete radiological response
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