Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Leiskau, C; Rajanayagam, J; Pfister, ED; Goldschmidt, I; Junge, N; Karch, A; Lerch, C; Richter, N; Lehner, F; Schrem, H; Baumann, U.
Side effects and efficacy of renal sparing immunosuppression in pediatric liver transplantation-A single center matched cohort study.
Pediatr Transplant. 2018; 22(5): e13207-e13207.
Web of Science PubMed FullText FullText_MUG


Autor/innen der Med Uni Graz:
Schrem Harald Heinrich

Dimensions Citations:

Plum Analytics:
Immunosuppressive combination therapy with MMF can reduce CNI associated nephrotoxicity. We investigated effectiveness and safety of de novo MMF-tacrolimus based immunosuppression after pLTx. Patients after pLTx receiving immunosuppression with MMF/tacrolimus (MMF/TAC) were compared to retrospectively selected age- and diagnosis-matched patients with tacrolimus monotherapy (TAC) and cyclosporine/prednisolone therapy (CSA) (19 patients each, n = 57). Effectiveness, renal function and side effects were analyzed for 1 year after pLTx. Tacrolimus reduction in combination therapy (0.7 μg/L over the year) was lower than aspired (2 μg/L). Acute BPAR occurred equally in MMF/TAC and TAC groups (31.6% each), being slightly higher in CSA group (42.1%; OR = 1.5; 95% CI = 0.42-5.44; P = .5). GFR deteriorated comparably in all 3 groups (P < .01 each) without significant differences between the groups. Septicemia was detected significantly more often in MMF/TAC (73.6%) than in TAC (31.6%) (OR 4.17; 1.07-16.27; P = .04). EBV reactivation occurred more often in CSA patients (84.2%) than in MMF/TAC (47.4%; OR 5.16; 0.98-27.19; P = .05) and TAC patients (52.6%; OR 8.16; 1.48-44.89; P = .02) the same was true for other viral infections (47.4% (CSA) vs 15.8% (TAC); OR 4.21; 0.95-18.55; P = .05). Our study does not provide additional evidence for a benefit of initial use of MMF/TAC over TAC regarding renal function, but raises concerns regarding a potentially increased risk of serious infections under MMF/TAC compared to TAC monotherapy at equivalent renal outcome; our study is, however, limited by the minor CNI reduction in combination therapy. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Calcineurin Inhibitors - therapeutic use
Child -
Child, Preschool -
Cyclosporine - therapeutic use
Drug Therapy, Combination -
Female -
Follow-Up Studies -
Graft Rejection - prevention & control
Humans -
Immunosuppressive Agents - therapeutic use
Infant -
Liver Transplantation -
Logistic Models -
Male -
Matched-Pair Analysis -
Mycophenolic Acid - therapeutic use
Prednisolone - therapeutic use
Renal Insufficiency - chemically induced
Renal Insufficiency - prevention & control
Retrospective Studies -
Tacrolimus - therapeutic use
Treatment Outcome -

Find related publications in this database (Keywords)
calcineurin inhibitor
mycophenolate mofetil
© Meduni Graz Impressum