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Damulina, A; Pirpamer, L; Seiler, S; Benke, T; Dal-Bianco, P; Ransmayr, G; Struhal, W; Hofer, E; Langkammer, C; Duering, M; Fazekas, F; Schmidt, R.
White Matter Hyperintensities in Alzheimer's Disease: A Lesion Probability Mapping Study.
J Alzheimers Dis. 2019; 68(2):789-796 Doi: 10.3233/JAD-180982
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Führende Autor*innen der Med Uni Graz
Damulina Anna
Schmidt Reinhold
Co-Autor*innen der Med Uni Graz
Fazekas Franz
Hofer Edith
Langkammer Christian
Pirpamer Lukas
Seiler Stephan

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Higher white matter hyperintensity (WMH) load has been reported in Alzheimer's disease (AD) patients in different brain regions when compared to controls. We aimed to assess possible differences of WMH spatial distribution between AD patients and age-matched controls by means of lesion probability maps. The present study included MRI scans of 130 probable AD patients with a mean age of 73.4±8.2 years from the Prospective Dementia Registry Austria Study and 130 age-matched healthy controls (HC) from the Austrian Stroke Prevention Family Study. Risk factors such as hypertension, diabetes mellitus, hypercholesterolemia, coronary artery disease, and smoking were assessed. Manually segmented FLAIR WMH masks were non-linearly registered to a template and voxel-based probability mapping was performed. There were no significant between-group differences in cardiovascular risk factors and WMH volume. AD patients showed a significantly higher likelihood of having WMH in a bilateral periventricular distribution than controls before and after correcting for age, sex, cardiovascular risk factors, and ventricular volume (p≤0.05; threshold-free cluster enhancement corrected). There was no significant association between the periventricular WMH volume and cognitive decline of AD patients. In AD, WMH were preferentially found in a periventricular location but the volume of lesions was unrelated to cognitive decline in our study irrespective of lesion location.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Aged, 80 and over -
Alzheimer Disease - diagnostic imaging
Alzheimer Disease - epidemiology
Alzheimer Disease - psychology
Alzheimer Disease - epidemiology
Brain - diagnostic imaging
Brain Mapping - methods
Cohort Studies -
Female -
Follow-Up Studies -
Humans -
Longitudinal Studies -
Male -
Middle Aged -
Prospective Studies -
Registries -
White Matter - diagnostic imaging

Find related publications in this database (Keywords)
Alzheimer's disease
magnetic resonance imaging
periventricular white matter
white matter hyperintensities
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