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Pichler, A; Khalil, M; Langkammer, C; Pinter, D; Ropele, S; Fuchs, S; Bachmaier, G; Enzinger, C; Fazekas, F.
The impact of vascular risk factors on brain volume and lesion load in patients with early multiple sclerosis.
Mult Scler. 2019; 25(1):48-54 Doi: 10.1177/1352458517736149
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Führende Autor*innen der Med Uni Graz
Pichler Alexander
Co-Autor*innen der Med Uni Graz
Bachmaier Gerhard
Enzinger Christian
Fazekas Franz
Fuchs Siegrid
Khalil Michael
Langkammer Christian
Pinter Daniela Theresia
Ropele Stefan

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BACKGROUND: Vascular risk factors (VRF) in multiple sclerosis (MS) patients have been associated with lower brain volumes. It is currently unknown if this association already exists in early MS and how it develops over time. METHODS: We identified 82 patients with clinically isolated syndrome (CIS) ( n = 61) or with early relapsing-remitting MS ( n = 21) and assessed their VRF including arterial hypertension, hyperlipidaemia, diabetes mellitus and smoking. We analysed T2-lesion load, normalized brain volume (NBV), cortical grey (cGMV) and white matter volumes (WMV), thalamic and basal ganglia volumes at baseline and follow-up magnetic resonance imaging (MRI) and assessed the percentage of brain volume change (PBVC) using SIENA. RESULTS: Patient mean age was 32.4 (±8.7) years and 54 (65%) were women. Median follow-up period was 42 (29-54) months. In total, 26 patients (31.7%) had one or more VRF (VRF+). At baseline, VRF+ patients had a lower NBV (1530.9 cm3 vs 1591.2 cm3, p = 0.001), a lower cGMV (628.5 cm3 vs 668.6 cm3, p = 0.002) and WMV (752.2 cm3 vs 783.9 cm3, p = 0.009) than VRF-negative patients. Similar results were obtained at follow-up. PBVC was comparable between patients with and without VRF. CONCLUSION: VRF are associated with lower brain volume already in early MS but do not lead to increased brain volume loss during 3.5 years of follow-up.
Find related publications in this database (using NLM MeSH Indexing)
Adult - administration & dosage
Brain - diagnostic imaging, pathology
Comorbidity - administration & dosage
Demyelinating Diseases - diagnostic imaging, epidemiology, pathology
Diabetes Mellitus - epidemiology
Female - administration & dosage
Follow-Up Studies - administration & dosage
Gray Matter - diagnostic imaging, pathology
Humans - administration & dosage
Hyperlipidemias - epidemiology
Hypertension - epidemiology
Magnetic Resonance Imaging - administration & dosage
Male - administration & dosage
Multiple Sclerosis, Relapsing-Remitting - diagnostic imaging, epidemiology, pathology
Risk Factors - administration & dosage
Smoking - epidemiology
White Matter - diagnostic imaging, pathology
Young Adult - administration & dosage

Find related publications in this database (Keywords)
Vascular risk factors
multiple sclerosis
brain volume
lesion load
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