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SHR Neuro Krebs Kardio Lipid

Rack, B; Zombirt, E; Trapp, E; Jückstock, J; Andergassen, U; Neugebauer, J; Kost, B; Weissenbacher, T; Jeschke, U; Schindlbeck, C; Janni, W; Alunni-Fabbroni, M.
Comparison of HER2 Expression in Primary Tumor and Disseminated Tumor Cells in the Bone Marrow of Breast Cancer Patients.
Oncology. 2016; 90(4):232-238 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG


Autor/innen der Med Uni Graz:
Trapp Elisabeth Katharina

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The aim of this study was to measure the human epidermal growth factor receptor 2 (HER2) status of disseminated tumor cells (DTCs) from bone marrow (BM) aspirates and to assess correspondence or discrepancy with the primary tumor. DTCs were isolated from the BM of 156 breast cancer patients. Cytokeratin-positive DTCs were further analyzed by the chromogenic in situ hybridization method to detect HER2 gene amplification. A significant correlation (p = 0.021) was found between the HER2 status of DTCs and the primary tumors. Sixty-one (68.5%) patients had a corresponding status. However, a shift of phenotype between primary tumor and DTCs was found in the remaining patients. This study showed a significant grade of discordance of the HER2 status between primary tumors and DTCs in the BM of a relevant subgroup of patients. Detection of HER2 amplification on DTCs could therefore help to better stratify patients for a more tailored therapy, since they would benefit from a HER2-targeted therapy. © 2016 S. Karger AG, Basel.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Aged, 80 and over -
Biomarkers, Tumor - genetics
Bone Marrow - pathology
Bone Marrow Cells - pathology
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Female -
Humans -
Middle Aged -
Neoplasm, Residual -
Neoplastic Cells, Circulating - pathology
Prognosis -
Receptor, ErbB-2 - biosynthesis
Receptor, ErbB-2 - genetics

Find related publications in this database (Keywords)
Breast cancer
Circulating tumor cells
Disseminated tumor cells
Minimal residual disease
Bone marrow
HER2-targeting agent
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