Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bugger, H; Abel, ED.
Mitochondria in the diabetic heart.
Cardiovasc Res. 2010; 88(2): 229-240.
Doi: 10.1093/cvr/cvq239
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- Führende Autor*innen der Med Uni Graz
- Bugger Heiko Matthias
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- Abstract:
- Diabetes mellitus increases the risk of developing cardiovascular diseases such as coronary artery disease and heart failure. Studies have shown that the heart failure risk is increased in diabetic patients even after adjusting for coronary artery disease and hypertension. Although the cause of this increased heart failure risk is multifactorial, increasing evidence suggests that derangements in cardiac energy metabolism play an important role. In particular, abnormalities in cardiomyocyte mitochondrial energetics appear to contribute substantially to the development of cardiac dysfunction in diabetes. This review will summarize these abnormalities in mitochondrial function and discuss potential underlying mechanisms.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Calcium - metabolism
- Diabetes Complications - etiology
- Diabetes Complications - metabolism
- Diabetes Complications - pathology
- Energy Metabolism -
- Heart Diseases - etiology
- Heart Diseases - metabolism
- Heart Diseases - pathology
- Humans -
- Insulin - metabolism
- Mitochondria, Heart - metabolism
- Mitochondria, Heart - pathology
- Mitochondrial Proteins - metabolism
- Myocardium - metabolism
- Myocardium - pathology
- Oxidative Stress -
- Protein Processing, Post-Translational -
- Risk Factors -
- Signal Transduction -
- Find related publications in this database (Keywords)
- Mitochondria
- Diabetes
- Heart
- Metabolism