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Sprengel, K; Simmen, H; Werner, CM; Sulser, S; Plecko, M; Keller, C; Mica, L.
Resuscitation with polymeric plasma substitutes is permissive for systemic inflammatory response syndrome and sepsis in multiply injured patients: a retrospective cohort study.
Eur J Med Res. 2016; 21(1): 39-39. [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Plecko Michael
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Abstract:
Multiple trauma is often accompanied by systemic inflammatory response syndrome (SIRS). The aim of this study was to investigate the impact of polymeric plasma substitutes on the development of SIRS or sepsis. We included 2969 patients aged ≥16 years with an Injury Severity Score (ISS) >16 in this study. The sample was subdivided into three groups: patients who did not receive colloids and those who received <5L colloids and >5L colloids within the first 48 h. Data were analyzed using IBM SPSS® for Windows version 22.0; analysis of variance was used for continuous normally distributed data and Kruskal-Wallis test for categorical data. The predictive quality of colloid treatment was analyzed using the receiver operating characteristic (ROC) curves. Independent predictively was analyzed by binary logistic regression. Data were considered significant if P < 0.05. Data are presented as the mean ± standard deviation. The SIRS score increased with the amount of colloid used (1.9 ± 1.4 vs. 2.4 ± 1.2 vs. 3.2 ± 0.9; P < 0.001). However, the predictive quality was low, with an area under the ROC of 0.693 for SIRS and 0.669 for sepsis (P < 0.001). Binary logistic regression revealed colloids as an independent factor for the development of SIRS and sepsis (odds ratios: SIRS 3.325 and sepsis 8.984; P < 0.001). Besides other factors, colloids have a significant permissive effect and are independent predictors for the development of SIRS and sepsis in multiply injured patients. Trial registration 'Retrospektive Analysen in der Chirurgischen Intensivmedizin' No. St. V. 01-2008.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Blood Transfusion - methods
Cohort Studies -
Female -
Humans -
Male -
Middle Aged -
Multiple Trauma - complications
Multiple Trauma - mortality
Multiple Trauma - therapy
Plasma Substitutes - therapeutic use
Resuscitation - methods
Retrospective Studies -
Sepsis - mortality
Sepsis - therapy
Systemic Inflammatory Response Syndrome - mortality
Systemic Inflammatory Response Syndrome - therapy
Treatment Outcome -

Find related publications in this database (Keywords)
Multiple trauma
Systemic inflammatory response syndrome
Sepsis
Hydroxyethyl starch derivatives
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