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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Merz, J; Albrecht, P; von Garlen, S; Ahmed, I; Dimanski, D; Wolf, D; Hilgendorf, I; Härdtner, C; Grotius, K; Willecke, F; Heidt, T; Bugger, H; Hoppe, N; Kintscher, U; von Zur Mühlen, C; Idzko, M; Bode, C; Zirlik, A; Stachon, P.
Purinergic receptor Y2 (P2Y2)- dependent VCAM-1 expression promotes immune cell infiltration in metabolic syndrome.
Basic Res Cardiol. 2018; 113(6):45-45 Doi: 10.1007/s00395-018-0702-1
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Co-Autor*innen der Med Uni Graz
Bugger Heiko Matthias
Zirlik Andreas

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Sterile inflammation of visceral fat, provoked by dying adipocytes, links the metabolic syndrome to cardiovascular disease. Danger-associated molecular patterns, such as adenosine triphosphate (ATP), are released by activated or dying cells and orchestrate leukocyte infiltration and inflammation via the purinergic receptor P2Y2. The gene expression of ATP receptor P2Y2 did not change in several tissues in the course of obesity, but was increased within epididymal fat. Adipose tissue from P2Y 2-/- mice consuming high-fat diet (HFD) contained less crown-like structures with a reduced frequency of adipose tissue macrophages (ATMs). This was likely due to decreased leukocyte migration because of missing VCAM-1 exposition on P2Y2 deficient hypertrophic adipose tissue endothelial cells. Accordingly, P2Y 2-/- mice showed blunted traits of the metabolic syndrome: they gained less weight compared to P2Y 2+/+ controls, while intake of food and movement behaviour remained unchanged. Liver and adipose tissue were smaller in P2Y 2-/- animals. Insulin tolerance testing (ITT) performed in obese P2Y 2-/- mice revealed a better insulin sensitivity as well as lower plasma C-peptide and cholesterol levels. We demonstrate that interfering with somatic P2Y2 signalling prevents excessive immune cell deposition in diet-induced obesity (DIO), both attenuating adipose tissue inflammation and ameliorating the metabolic phenotype. Thus, blocking the P2Y2 cascade may be a promising strategy to limit metabolic disease and its sequelae.
Find related publications in this database (using NLM MeSH Indexing)
Adipose Tissue - metabolism
Adipose Tissue - pathology
Animals -
Chemotaxis, Leukocyte - physiology
Diet, High-Fat -
Inflammation - metabolism
Inflammation - pathology
Male -
Metabolic Syndrome - metabolism
Metabolic Syndrome - pathology
Mice -
Mice, Inbred C57BL -
Mice, Knockout -
Obesity - metabolism
Receptors, Purinergic P2Y2 - metabolism
Vascular Cell Adhesion Molecule-1 - metabolism

Find related publications in this database (Keywords)
Metabolic syndrome
Purinergic receptors
Immune cell infiltration
Find-me signal
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