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Brix, M; Buschmann, EE; Zietzer, A; Jaurigue, JA; Li, L; Jungk, C; Buschmann, I; Janke, D; Hillmeister, P.
Long-term individual shear rate therapy counterpulsation enhances plasma nitrite release in patients with PAD.
Vasa. 2017; 46(1): 37-45. [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Buschmann Eva Elina
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Abstract:
Individual shear rate therapy (ISRT) has been designed as a novel non-invasive treatment option for peripheral artery disease (PAD) patients and has been shown to improve endothelial function and walking distance. The aim of this study was to elucidate the impact of ISRT on the level of nitric oxide in patient blood plasma and the expression of related molecular markers in peripheral blood mononuclear cells (PBMCs). Molecular diagnostic tests were performed for two ISRT trials. In ISRT-1 26 healthy subjects underwent one session of treadmill training and one session of ISRT respectively in a cross-over design. In ISRT-2 14 PAD patients with a stable intermittent claudication underwent a 30 hours long-term treatment. Plasma nitrite release as well as the mRNA expression of NOS2 and key regulators of the kallikrein-kinin system were measured in PBMCs at different time points. Short-term ISRT revealed significantly decreased NOS2 expression in PBMCs of healthy volunteers and PAD patients. Long-term ISRT, in turn, demonstrated a significant plasma nitrite increase in PAD patients. We verified that long-term ISRT stimulates the vascular system and exerts a comparable effect to physical exercise in regards to NO release, which coincide with recent findings regarding an improvement of endothelial function. However, further studies are necessary to investigate the role for circulating leukocytes.
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Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Adult -
Aged -
Aged, 80 and over -
Biomarkers - blood
Counterpulsation - methods
Cross-Over Studies -
Exercise Test -
Female -
Humans -
Intermittent Claudication - blood
Intermittent Claudication - diagnosis
Intermittent Claudication - physiopathology
Intermittent Claudication - therapy
Kallikrein-Kinin System - genetics
Leukocytes, Mononuclear - enzymology
Male -
Middle Aged -
Nitric Oxide - blood
Nitric Oxide Synthase Type II - blood
Nitric Oxide Synthase Type II - genetics
Nitrites - blood
Peripheral Arterial Disease - blood
Peripheral Arterial Disease - diagnosis
Peripheral Arterial Disease - physiopathology
Peripheral Arterial Disease - therapy
RNA, Messenger - blood
RNA, Messenger - genetics
Stress, Mechanical -
Time Factors -
Treatment Outcome -
Young Adult -

Find related publications in this database (Keywords)
Peripheral vascular disease
exercise
exercise testing
rehabilitation
gene expression endothelium
vascular type
nitric oxide
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