Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Olschewski, A; Berghausen, EM; Eichstaedt, CA; Fleischmann, BK; Grünig, E; Grünig, G; Hansmann, G; Harbaum, L; Hennigs, JK; Jonigk, D; Kuebler, WM; Kwapiszewska, G; Pullamsetti, SS; Stacher, E; Weissmann, N; Wenzel, D; Schermuly, RT.
Pathobiology, pathology and genetics of pulmonary hypertension: Update from the Cologne Consensus Conference 2018.
Int J Cardiol. 2018; 272S(10): 4-10.
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Autor/innen der Med Uni Graz:
Kwapiszewska-Marsh Grazyna
Olschewski Andrea
Stacher-Priehse Elvira

Dimensions Citations:

Plum Analytics:
The European guidelines, which focus on clinical aspects of pulmonary hypertension (PH), provide only minimal information about the pathophysiological concepts of PH. Here, we review this topic in greater detail, focusing on specific aspects in the pathobiology, pathology and genetics, which include mechanisms of vascular inflammation, the role of transcription factors, ion channels/ion channel diseases, hypoxic pulmonary vasoconstriction, genetics/epigenetics, metabolic dysfunction, and the potential future role of histopathology of PH in the modern era of PH therapy. In addition to new insights in the pathobiology of this disease, this working group of the Cologne Consensus Conference also highlights novel concepts and potential new therapeutic targets to further improve the treatment options in PAH. Copyright © 2018. Published by Elsevier B.V.

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