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SHR Neuro Krebs Kardio Lipid

Pilz, S; Zittermann, A; Obeid, R; Hahn, A; Pludowski, P; Trummer, C; Lerchbaum, E; Pérez-López, FR; Karras, SN; März, W.
The Role of Vitamin D in Fertility and during Pregnancy and Lactation: A Review of Clinical Data.
Int J Environ Res Public Health. 2018; 15(10): 2241 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Lerchbaum Elisabeth
Maerz Winfried
Pilz Stefan
Trummer Christian
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Abstract:
Vitamin D deficiency is common and there exists a huge gap between recommended dietary vitamin D intakes and the poor vitamin D supply in the general population. While vitamin D is important for musculoskeletal health, there are accumulating data suggesting that vitamin D may also be important for fertility, pregnancy outcomes and lactation. Significant changes in vitamin D metabolism during pregnancy such as increased production of the "active vitamin D hormone" calcitriol support the important role of vitamin D in this setting. Observational studies show that vitamin D deficiency is a risk marker for reduced fertility and various adverse pregnancy outcomes and is associated with a low vitamin D content of breast milk. Meta-analyses of randomized controlled trials (RCTs) document that physiological vitamin D supplementation during pregnancy is safe and improves vitamin D and calcium status, thereby protecting skeletal health. Although certain RCTs and/or meta-analyses reported some other beneficial effects, it is still not clear whether vitamin D supplementation improves fertility or decreases the risk of adverse pregnancy outcomes such as low birth weight, pre-eclampsia and neonatal mortality, or reduces wheeze/asthma in the infants. Nevertheless, vitamin D supplementation in pregnant women is frequently required to achieve a sufficient vitamin D status as recommended by nutritional vitamin D guidelines. In this review, we provide an overview of systematic reviews, meta-analyses and large trials reporting clinical data on the role of vitamin D for fertility, pregnancy and lactation.

Find related publications in this database (Keywords)
vitamin D
gestational diabetes
pre-eclampsia
breast milk
vitamin D binding protein
DBP
brain
autism
25-hydroxyvitamin D
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