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SHR Neuro Krebs Kardio Lipid

Faustmann, G; Meinitzer, A; Magnes, C; Tiran, B; Obermayer-Pietsch, B; Gruber, HJ; Ribalta, J; Rock, E; Roob, JM; Winklhofer-Roob, BM.
Progesterone-associated arginine decline at luteal phase of menstrual cycle and associations with related amino acids and nuclear factor kB activation.
PLoS One. 2018; 13(7):e0200489-e0200489 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Faustmann Gernot
Gruber Hans-Jürgen
Meinitzer Andreas
Obermayer-Pietsch Barbara
Roob Johannes
Tiran Beate
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Number of Figures: 9
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Abstract:
Given their role in female reproduction, the effects of progesterone on arginine and related amino acids, polyamines and NF-κB p65 activation were studied across the menstrual cycle. Arginine, ornithine and citrulline as well as putrescine, spermidine, spermine, and N-acetyl-putrescine were determined in plasma, NF-κB p65 activation in peripheral blood mononuclear cells and progesterone in serum of 28 women at early (T1) and late follicular (T2) and mid (T3) and late (T4) luteal phase. Arginine and related amino acids declined from T1 and T2 to T3 and T4, while progesterone increased. At T3, arginine, ornithine, and citrulline were inversely related with progesterone. Changes (ΔT3-T2) in arginine, ornithine, and citrulline were inversely related with changes (ΔT3-T2) in progesterone. Ornithine and citrulline were positively related with arginine, as were changes (ΔT3-T2) in ornithine and citrulline with changes (ΔT3-T2) in arginine. At T2, NF-κB p65 activation was positively related with arginine. Polyamines did not change and were not related to progesterone. All results described were significant at P < 0.001. This study for the first time provides data, at the plasma and PBMC level, supporting a proposed regulatory node of arginine and related amino acids, progesterone and NF-κB p65 at luteal phase of the menstrual cycle, aimed at successful preparation of pregnancy.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Amino Acids - blood
Arginine - blood
Citrulline - metabolism
Female -
Follicular Phase -
Healthy Volunteers -
Humans -
Leukocytes, Mononuclear - cytology
Luteal Phase - blood
NF-kappa B p50 Subunit - blood
Ornithine - metabolism
Progesterone - physiology
Putrescine - metabolism
Reference Values -
Spermidine - metabolism
Spermine - metabolism
Transcription Factor RelA - blood

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