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SHR Neuro Krebs Kardio Lipid

Habre, W; Disma, N; Virag, K; Becke, K; Hansen, TG; Jöhr, M; Leva, B; Morton, NS; Vermeulen, PM; Zielinska, M; Boda, K; Veyckemans, F; APRICOT Group of the European Society of Anaesthesiology Clinical Trial Network.
Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe.
Lancet Respir Med. 2017; 5(5):412-425
Web of Science PubMed FullText FullText_MUG


Study Group Mitglieder der Med Uni Graz:
Messerer Brigitte
Vittinghoff Maria

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Plum Analytics:
Little is known about the incidence of severe critical events in children undergoing general anaesthesia in Europe. We aimed to identify the incidence, nature, and outcome of severe critical events in children undergoing anaesthesia, and the associated potential risk factors. The APRICOT study was a prospective observational multicentre cohort study of children from birth to 15 years of age undergoing elective or urgent anaesthesia for diagnostic or surgical procedures. Children were eligible for inclusion during a 2-week period determined prospectively by each centre. There were 261 participating centres across 33 European countries. The primary endpoint was the occurence of perioperative severe critical events requiring immediate intervention. A severe critical event was defined as the occurrence of respiratory, cardiac, allergic, or neurological complications requiring immediate intervention and that led (or could have led) to major disability or death. This study is registered with, number NCT01878760. Between April 1, 2014, and Jan 31, 2015, 31 127 anaesthetic procedures in 30 874 children with a mean age of 6·35 years (SD 4·50) were included. The incidence of perioperative severe critical events was 5·2% (95% CI 5·0-5·5) with an incidence of respiratory critical events of 3·1% (2·9-3·3). Cardiovascular instability occurred in 1·9% (1·7-2·1), with an immediate poor outcome in 5·4% (3·7-7·5) of these cases. The all-cause 30-day in-hospital mortality rate was 10 in 10 000. This was independent of type of anaesthesia. Age (relative risk 0·88, 95% CI 0·86-0·90; p<0·0001), medical history, and physical condition (1·60, 1·40-1·82; p<0·0001) were the major risk factors for a serious critical event. Multivariate analysis revealed evidence for the beneficial effect of years of experience of the most senior anaesthesia team member (0·99, 0·981-0·997; p<0·0048 for respiratory critical events, and 0·98, 0·97-0·99; p=0·0039 for cardiovascular critical events), rather than the type of health institution or providers. This study highlights a relatively high rate of severe critical events during the anaesthesia management of children for surgical or diagnostic procedures in Europe, and a large variability in the practice of paediatric anaesthesia. These findings are substantial enough to warrant attention from national, regional, and specialist societies to target education of anaesthesiologists and their teams and implement strategies for quality improvement in paediatric anaesthesia. European Society of Anaesthesiology. Copyright © 2017 Elsevier Ltd. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Age Factors -
Anesthesia, General - adverse effects
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - etiology
Child -
Child, Preschool -
Clinical Competence -
Drug Hypersensitivity - epidemiology
Drug Hypersensitivity - etiology
Europe - epidemiology
Female -
Health Status -
Hospitals - statistics & numerical data
Humans -
Incidence -
Infant -
Infant, Newborn -
Intraoperative Complications - epidemiology
Intraoperative Complications - etiology
Male -
Nervous System Diseases - epidemiology
Nervous System Diseases - etiology
Postoperative Complications - epidemiology
Postoperative Complications - etiology
Prospective Studies -
Respiratory Tract Diseases - epidemiology
Respiratory Tract Diseases - etiology

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