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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Dobsak, T; Heimel, P; Tangl, S; Schwarze, UY; Schett, G; Gruber, R.
Impaired periodontium and temporomandibular joints in tumour necrosis factor-α transgenic mice.
J Clin Periodontol. 2017; 44(12):1226-1235
Web of Science PubMed FullText FullText_MUG


Autor/innen der Med Uni Graz:
Schwarze Uwe Yacine

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Plum Analytics:
Tumour necrosis factor (TNF)-α is a pathological factor causing the characteristic symptoms of periodontal disease and rheumatoid arthritis. In this study, we describe the phenotypes of human TNF-α transgenic mice (hTNFtg) with respect to their periodontium and the temporomandibular joint (TMJ). Periodontal structures, TMJ and skull shape of hTNFtg mice and wild-type (WT) littermates were assessed by microcomputed tomography, automated segmentation, geometric morphometrics and histologic ground sections. We show that hTNFtg mice have an eroded lamina dura and reduced periodontal ligament space compared to (WT) littermates. Transgenic mice further exhibit severe destruction of the TMJ. Geometric morphometrics revealed that hTNFtg mice have a more laterally positioned TMJ with a concomitantly enlarged zygomatic process. Mandibular and maxillary teeth occluded properly. Our findings suggest that chronic inflammation in hTNFtg mice causes destructive changes of the periodontium and the TMJ. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Arthritis, Rheumatoid -
Bone Resorption - pathology
Humans -
Inflammation -
Mice -
Mice, Transgenic -
Osteoclasts - pathology
Periodontal Ligament - anatomy & histology
Periodontal Ligament - pathology
Periodontium - anatomy & histology
Periodontium - diagnostic imaging
Periodontium - pathology
Phenotype -
Skull - anatomy & histology
Temporomandibular Joint - anatomy & histology
Temporomandibular Joint - diagnostic imaging
Temporomandibular Joint - physiology
Tumor Necrosis Factor-alpha - genetics
Tumor Necrosis Factor-alpha - physiology
X-Ray Microtomography -
Zygoma - anatomy & histology

Find related publications in this database (Keywords)
geometric morphometrics
rheumatoid arthritis
temporomandibular joints
tumour necrosis factor-
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