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SHR Neuro Krebs Kardio Lipid

Todenhöfer, T; Hennenlotter, J; Feyerabend, S; Aufderklamm, S; Mischinger, J; Kühs, U; Gerber, V; Fetisch, J; Schilling, D; Hauch, S; Stenzl, A; Schwentner, C.
Preliminary experience on the use of the Adnatest® system for detection of circulating tumor cells in prostate cancer patients.
Anticancer Res. 2012; 32(8):3507-3513
Web of Science PubMed

 

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Abstract:
The Adnatest® system combines immunomagnetic enrichment of epithelial cells with polymerase chain reaction for prostate cancer (PC)-specific transcripts for the detection circulating tumor cells (CTCs). We evaluated the Adnatest® in patients with castration-resistant PC receiving docetaxel chemotherapy. CTCs were assessed in 16 patients with castration-resistant PC before cycles one and three of chemotherapy. Furthermore, markers of stem cells and epithelial-mesenchymal transition were assessed. Treatment response was assessed by imaging and prostate-specific antigen measurements. Before chemotherapy, 11 patients were Adnatest®-positive whereas five patients were Adnatest®-positive before cycle three. A positive Adnatest® correlated with radiological progression (p=0.02). Rates of disease progression in epidermal growth factor receptor (EGFR)-positive and -negative patients were 100% and 7.7% (p=0.03). In this preliminary study, the Adnatest® detected CTCs in a considerable proportion of patients with castration-resistant PC. First data on certain markers (EGFR and aldehyd dehydrogenase 1) encourage future studies investigating transcripts predicting treatment response.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Antineoplastic Agents - therapeutic use
Humans -
Male -
Middle Aged -
Neoplastic Cells, Circulating -
Polymerase Chain Reaction -
Prostatic Neoplasms - blood
Prostatic Neoplasms - drug therapy
Prostatic Neoplasms - pathology
RNA, Messenger - genetics
Taxoids - therapeutic use

Find related publications in this database (Keywords)
Adnatest
CTC
chemotherapy
prostate cancer
response
prognosis
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